Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1)
1_MDQDY 6_ ERRLL 11_ RQIVI 16_ QNENT 21_ MPRVT 26_ EMRRT 31_ LTPAS 36_ SPVSS 41_ PSKHG 46_ DRFIP 51_ SRAGA 56_ NWSVN 61_ FHRIN 66_ ENEKS 71_ PSQNR 76_ KAKDA 81_ TSDNG 86_ KDGLA 91_ YSALL 96_ KNELL 101_ GAGIE 106_ KVQDP 111_ QTEDR 116_ RLQPS 121_ TPEKK 126_ GLFTY 131_ SLSTK 136_ RSSPD 141_ DGNDV 146_ SPYSL 151_ SPVSN 156_ KSQKL 161_ LRSPR 166_ KPTRK 171_ ISKIP 176_ FKVLD 181_ APELQ 186_ DDFYL 191_ NLVDW 196_ SSLNV 201_ LSVGL 206_ GTCVY 211_ LWSAC 216_ TSQVT 221_ RLCDL 226_ SVEGD 231_ SVTSV 236_ GWSER 241_ GNLVA 246_ VGTHK 251_ GFVQI 256_ WDAAA 261_ GKKLS 266_ MLEGH 271_ TARVG 276_ ALAWN 281_ AEQLS 286_ SGSRD 291_ RMILQ 296_ RDIRT 301_ PPLQS 306_ ERRLQ 311_ GHRQE 316_ VCGLK 321_ WSTDH 326_ QLLAS 331_ GGNDN 336_ KLLVW 341_ NHSSL 346_ SPVQQ 351_ YTEHL 356_ AAVKA 361_ IAWSP 366_ HQHGL 371_ LASGG 376_ GTADR 381_ CIRFW 386_ NTLTG 391_ QPLQC 396_ IDTGS 401_ QVCNL 406_ AWSKH 411_ ANELV 416_ STHGY 421_ SQNQI 426_ LVWKY 431_ PSLTQ 436_ VAKLT 441_ GHSYR 446_ VLYLA 451_ MSPDG 456_ EAIVT 461_ GAGDE 466_ TLRFW 471_ NVFSK 476_ TRSTK 481_ VKWES 486_ VSVLN 491_LFTRI
1: Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192)