Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10)
1_MTTPN 6_ KTPPG 11_ ADPKQ 16_ LERTG 21_ TVREI 26_ GSQAV 31_ WSLSS 36_ CKPGF 41_ GVDQL 46_ RDDNL 51_ ETYWQ 56_ SDGSQ 61_ PHLVN 66_ IQFRR 71_ KTTVK 76_ TLCIY 81_ ADYKS 86_ DESYT 91_ PSKIS 96_ VRVGN 101_ NFHNL 106_ QEIRQ 111_ LELVE 116_ PSGWI 121_ HVPLT 126_ DNHKK 131_ PTRTF 136_ MIQIA 141_ VLANH 146_ QNGRD 151_ THMRQ 156_ IKIYT 161_ PVEES 166_ SIGKF 171_ PRCTT 176_IDFMM
1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132)