Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
1_MGPGA 6_ RGRRR 11_ RRRPM 16_ SPPPP 21_ PPPVR 26_ ALPLL 31_ LLLAG 36_ PGAAA 41_ PPCLD 46_ GSPCA 51_ NGGRC 56_ TQLPS 61_ REAAC 66_ LCPPG 71_ WVGER 76_ CQLED 81_ PCHSG 86_ PCAGR 91_ GVCQS 96_ SVVAG 101_ TARFS 106_ CRCPR 111_ GFRGP 116_ DCSLP 121_ DPCLS 126_ SPCAH 131_ GARCS 136_ VGPDG 141_ RFLCS 146_ CPPGY 151_ QGRSC 156_ RSDVD 161_ ECRVG 166_ EPCRH 171_ GGTCL 176_ NTPGS 181_ FRCQC 186_ PAGYT 191_ GPLCE 196_ NPAVP 201_ CAPSP 206_ CRNGG 211_ TCRQS 216_ GDLTY 221_ DCACL 226_ PGFEG 231_ QNCEV 236_ NVDDC 241_ PGHRC 246_ LNGGT 251_ CVDGV 256_ NTYNC 261_ QCPPE 266_ WTGQF 271_ CTEDV 276_ DECQL 281_ QPNAC 286_ HNGGT 291_ CFNTL 296_ GGHSC 301_ VCVNG 306_ WTGES 311_ CSQNI 316_ DDCAT 321_ AVCFH 326_ GATCH 331_ DRVAS 336_ FYCAC 341_ PMGKT 346_ GLLCH 351_ LDDAC 356_ VSNPC 361_ HEDAI 366_ CDTNP 371_ VNGRA 376_ ICTCP 381_ PGFTG 386_ GACDQ 391_ DVDEC 396_ SIGAN 401_ PCEHL 406_ GRCVN 411_ TQGSF 416_ LCQCG 421_ RGYTG 426_ PRCET 431_ DVNEC 436_ LSGPC 441_ RNQAT 446_ CLDRI 451_ GQFTC 456_ ICMAG 461_ FTGTY 466_ CEVDI 471_ DECQS 476_ SPCVN 481_ GGVCK 486_ DRVNG 491_ FSCTC 496_ PSGFS 501_ GSTCQ 506_ LDVDE 511_ CASTP 516_ CRNGA 521_ KCVDQ 526_ PDGYE 531_ CRCAE 536_ GFEGT 541_ LCDRN 546_ VDDCS 551_ PDPCH 556_ HGRCV 561_ DGIAS 566_ FSCAC 571_ APGYT 576_ GTRCE 581_ SQVDE 586_ CRSQP 591_ CRHGG 596_ KCLDL 601_ VDKYL 606_ CRCPS 611_ GTTGV 616_ NCEVN 621_ IDDCA 626_ SNPCT 631_ FGVCR 636_ DGINR 641_ YDCVC 646_ QPGFT 651_ GPLCN 656_ VEINE 661_ CASSP 666_ CGEGG 671_ SCVDG 676_ ENGFR 681_ CLCPP 686_ GSLPP 691_ LCLPP 696_ SHPCA 701_ HEPCS 706_ HGICY 711_ DAPGG 716_ FRCVC 721_ EPGWS 726_ GPRCS 731_ QSLAR 736_ DACES 741_ QPCRA 746_ GGTCS 751_ SDGMG 756_ FHCTC 761_ PPGVQ 766_ GRQCE 771_ LLSPC 776_ TPNPC 781_ EHGGR 786_ CESAP 791_ GQLPV 796_ CSCPQ 801_ GWQGP 806_ RCQQD 811_ VDECA 816_ GPAPC 821_ GPHGI 826_ CTNLA 831_ GSFSC 836_ TCHGG 841_ YTGPS 846_ CDQDI 851_ NDCDP 856_ NPCLN 861_ GGSCQ 866_ DGVGS 871_ FSCSC 876_ LPGFA 881_ GPRCA 886_ RDVDE 891_ CLSNP 896_ CGPGT 901_ CTDHV 906_ ASFTC 911_ TCPPG 916_ YGGFH 921_ CEQDL 926_ PDCSP 931_ SSCFN 936_ GGTCV 941_ DGVNS 946_ FSCLC 951_ RPGYT 956_ GAHCQ 961_ HEADP 966_ CLSRP 971_ CLHGG 976_ VCSAA 981_ HPGFR 986_ CTCLE 991_ SFTGP 996_ QCQTL 1001_ VDWCS 1006_ RQPCQ 1011_ NGGRC 1016_ VQTGA 1021_ YCLCP 1026_ PGWSG 1031_ RLCDI 1036_ RSLPC 1041_ REAAA 1046_ QIGVR 1051_ LEQLC 1056_ QAGGQ 1061_ CVDED 1066_ SSHYC 1071_ VCPEG 1076_ RTGSH 1081_ CEQEV 1086_ DPCLA 1091_ QPCQH 1096_ GGTCR 1101_ GYMGG 1106_ YMCEC 1111_ LPGYN 1116_ GDNCE 1121_ DDVDE 1126_ CASQP 1131_ CQHGG 1136_ SCIDL 1141_ VARYL 1146_ CSCPP 1151_ GTLGV 1156_ LCEIN 1161_ EDDCG 1166_ PGPPL 1171_ DSGPR 1176_ CLHNG 1181_ TCVDL 1186_ VGGFR 1191_ CTCPP 1196_ GYTGL 1201_ RCEAD 1206_ INECR 1211_ SGACH 1216_ AAHTR 1221_ DCLQD 1226_ PGGGF 1231_ RCLCH 1236_ AGFSG 1241_ PRCQT 1246_ VLSPC 1251_ ESQPC 1256_ QHGGQ 1261_ CRPSP 1266_ GPGGG 1271_ LTFTC 1276_ HCAQP 1281_ FWGPR 1286_ CERVA 1291_ RSCRE 1296_ LQCPV 1301_ GVPCQ 1306_ QTPRG 1311_ PRCAC 1316_ PPGLS 1321_ GPSCR 1326_ SFPGS 1331_ PPGAS 1336_ NASCA 1341_ AAPCL 1346_ HGGSC 1351_ RPAPL 1356_ APFFR 1361_ CACAQ 1366_ GWTGP 1371_ RCEAP 1376_ AAAPE 1381_ VSEEP 1386_ RCPRA 1391_ ACQAK 1396_ RGDQR 1401_ CDREC 1406_ NSPGC 1411_ GWDGG 1416_ DCSLS 1421_ VGDPW 1426_ RQCEA 1431_ LQCWR 1436_ LFNNS 1441_ RCDPA 1446_ CSSPA 1451_ CLYDN 1456_ FDCHA 1461_ GGRER 1466_ TCNPV 1471_ YEKYC 1476_ ADHFA 1481_ DGRCD 1486_ QGCNT 1491_ EECGW 1496_ DGLDC 1501_ ASEVP 1506_ ALLAR 1511_ GVLVL 1516_ TVLLP 1521_ PEELL 1526_ RSSAD 1531_ FLQRL 1536_ SAILR 1541_ TSLRF 1546_ RLDAH 1551_ GQAMV 1556_ FPYHR 1561_ PSPGS 1566_ EPRAR 1571_ RELAP 1576_ EVIGS 1581_ VVMLE 1586_ IDNRL 1591_ CLQSP 1596_ ENDHC 1601_ FPDAQ 1606_ SAADY 1611_ LGALS 1616_ AVERL 1621_ DFPYP 1626_ LRDVR 1631_ GEPLE 1636_ PPEPS 1641_ VPLLP 1646_ LLVAG 1651_ AVLLL 1656_ VILVL 1661_ GVMVA 1666_ RRKRE 1671_ HSTLW 1676_ FPEGF 1681_ SLHKD 1686_ VASGH 1691_ KGRRE 1696_ PVGQD 1701_ ALGMK 1706_ NMAKG 1711_ ESLMG 1716_ EVATD 1721_ WMDTE 1726_ CPEAK 1731_ RLKVE 1736_ EPGMG 1741_ AEEAV 1746_ DCRQW 1751_ TQHHL 1756_ VAADI 1761_ RVAPA 1766_ MALTP 1771_ PQGDA 1776_ DADGM 1781_ DVNVR 1786_ GPDGF 1791_ TPLML 1796_ ASFCG 1801_ GALEP 1806_ MPTEE 1811_ DEADD 1816_ TSASI 1821_ ISDLI 1826_ CQGAQ 1831_ LGART 1836_ DRTGE 1841_ TALHL 1846_ AARYA 1851_ RADAA 1856_ KRLLD 1861_ AGADT 1866_ NAQDH 1871_ SGRTP 1876_ LHTAV 1881_ TADAQ 1886_ GVFQI 1891_ LIRNR 1896_ STDLD 1901_ ARMAD 1906_ GSTAL 1911_ ILAAR 1916_ LAVEG 1921_ MVEEL 1926_ IASHA 1931_ DVNAV 1936_ DELGK 1941_ SALHW 1946_ AAAVN 1951_ NVEAT 1956_ LALLK 1961_ NGANK 1966_ DMQDS 1971_ KEETP 1976_ LFLAA 1981_ REGSY 1986_ EAAKL 1991_ LLDHF 1996_ ANREI 2001_ TDHLD 2006_ RLPRD 2011_ VAQER 2016_ LHQDI 2021_ VRLLD 2026_ QPSGP 2031_ RSPPG 2036_ PHGLG 2041_ PLLCP 2046_ PGAFL 2051_ PGLKA 2056_ AQSGS 2061_ KKSRR 2066_ PPGKA 2071_ GLGPQ 2076_ GPRGR 2081_ GKKLT 2086_ LACPG 2091_ PLADS 2096_ SVTLS 2101_ PVDSL 2106_ DSPRP 2111_ FGGPP 2116_ ASPGG 2121_ FPLEG 2126_ PYAAA 2131_ TATAV 2136_ SLAQL 2141_ GGPGR 2146_ AGLGR 2151_ QPPGG 2156_ CVLSL 2161_ GLLNP 2166_ VAVPL 2171_ DWARL 2176_ PPPAP 2181_ PGPSF 2186_ LLPLA 2191_ PGPQL 2196_ LNPGT 2201_ PVSPQ 2206_ ERPPP 2211_ YLAVP 2216_ GHGEE 2221_ YPAAG 2226_ AHSSP 2231_ PKARF 2236_ LRVPS 2241_ EHPYL 2246_ TPSPE 2251_ SPEHW 2256_ ASPSP 2261_ PSLSD 2266_ WSEST 2271_ PSPAT 2276_ ATGAM 2281_ ATTTG 2286_ ALPAQ 2291_ PLPLS 2296_ VPSSL 2301_ AQAQT 2306_ QLGPQ 2311_ PEVTP 2316_KRQVL
1: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity)