Unconventional myosin-VI (Unconventional myosin-6)
1_MEDGK 6_ PVWAP 11_ HPTDG 16_ FQMGN 21_ IVDIG 26_ PDSLT 31_ IEPLN 36_ QKGKT 41_ FLALI 46_ NQVFP 51_ AEEDS 56_ KKDVE 61_ DNCSL 66_ MYLNE 71_ ATLLH 76_ NIKVR 81_ YSKDR 86_ IYTYV 91_ ANILI 96_ AVNPY 101_ FDIPK 106_ IYSSE 111_ AIKSY 116_ QGKSL 121_ GTRPP 126_ HVFAI 131_ ADKAF 136_ RDMKV 141_ LKMSQ 146_ SIIVS 151_ GESGA 156_ GKTEN 161_ TKFVL 166_ RYLTE 171_ SYGTG 176_ QDIDD 181_ RIVEA 186_ NPLLE 191_ AFGNA 196_ KTVRN 201_ NNSSR 206_ FGKFV 211_ EIHFN 216_ EKSSV 221_ VGGFV 226_ SHYLL 231_ EKSRI 236_ CVQGK 241_ EERNY 246_ HIFYR 251_ LCAGA 256_ SEDIR 261_ EKLHL 266_ SSPDN 271_ FRYLN 276_ RGCTR 281_ YFANK 286_ ETDKQ 291_ ILQNR 296_ KSPEY 301_ LKAGS 306_ MKDPL 311_ LDDHG 316_ DFIRM 321_ CTAMK 326_ KIGLD 331_ DEEKL 336_ DLFRV 341_ VAGVL 346_ HLGNI 351_ DFEEA 356_ GSTSG 361_ GCNLK 366_ NKSAQ 371_ SLEYC 376_ AELLG 381_ LDQDD 386_ LRVSL 391_ TTRVM 396_ LTTAG 401_ GTKGT 406_ VIKVP 411_ LKVEQ 416_ ANNAR 421_ DALAK 426_ TVYSH 431_ LFDHV 436_ VNRVN 441_ QCFPF 446_ ETSSY 451_ FIGVL 456_ DIAGF 461_ EYFEH 466_ NSFEQ 471_ FCINY 476_ CNEKL 481_ QQFFN 486_ ERILK 491_ EEQEL 496_ YQKEG 501_ LGVNE 506_ VHYVD 511_ NQDCI 516_ DLIEA 521_ KLVGI 526_ LDILD 531_ EENRL 536_ PQPSD 541_ QHFTS 546_ AVHQK 551_ HKDHF 556_ RLTIP 561_ RKSKL 566_ AVHRN 571_ IRDDE 576_ GFIIR 581_ HFAGA 586_ VCYET 591_ TQFVE 596_ KNNDA 601_ LHMSL 606_ ESLIC 611_ ESRDK 616_ FIREL 621_ FESST 626_ NNNKD 631_ TKQKA 636_ GKLSF 641_ ISVGN 646_ KFKTQ 651_ LNLLL 656_ DKLRS 661_ TGASF 666_ IRCIK 671_ PNLKM 676_ TSHHF 681_ EGAQI 686_ LSQLQ 691_ CSGMV 696_ SVLDL 701_ MQGGY 706_ PSRAS 711_ FHELY 716_ NMYKK 721_ YMPDK 726_ LARLD 731_ PRLFC 736_ KALFK 741_ ALGLN 746_ ENDYK 751_ FGLTK 756_ VFFRP 761_ GKFAE 766_ FDQIM 771_ KSDPD 776_ HLAEL 781_ VKRVN 786_ HWLTC 791_ SRWKK 796_ VQWCS 801_ LSVIK 806_ LKNKI 811_ KYRAE 816_ ACIKM 821_ QKTIR 826_ MWLCK 831_ RRHKP 836_ RIDGL 841_ VKVGT 846_ LKKRL 851_ DKFNE 856_ VVSVL 861_ KDGKP 866_ EMNKQ 871_ IKNLE 876_ ISIDT 881_ LMAKI 886_ KSTMM 891_ TQEQI 896_ QKEYD 901_ ALVKS 906_ SEELL 911_ SALQK 916_ KKQQE 921_ EEAER 926_ LRRIQ 931_ EEMEK 936_ ERKRR 941_ EEDEK 946_ RRRKE 951_ EEERR 956_ MKLEM 961_ EAKRK 966_ QEEEE 971_ RKKRE 976_ DDEKR 981_ IQAEV 986_ EAQLA 991_ RQKEE 996_ ESQQQ 1001_ AVLEQ 1006_ ERRDR 1011_ ELALR 1016_ IAQSE 1021_ AELIS 1026_ DEAQA 1031_ DLALR 1036_ RSLDS 1041_ YPVSK 1046_ NDGTR 1051_ PKMTP 1056_ EQMAK 1061_ EMSEF 1066_ LSRGP 1071_ AVLAT 1076_ KAAAG 1081_ TKKYD 1086_ LSKWK 1091_ YAELR 1096_ DTINT 1101_ SCDIE 1106_ LLAAC 1111_ REEFH 1116_ RRLKV 1121_ YHAWK 1126_ SKNKK 1131_ RNTET 1136_ EQRAP 1141_ KSVTD 1146_ YDFAP 1151_ FLNNS 1156_ PQQNP 1161_ AAQIP 1166_ ARQRE 1171_ IEMNR 1176_ QQRFF 1181_ RIPFI 1186_ RPADQ 1191_ YKDPQ 1196_ SKKKG 1201_ WWYAH 1206_ FDGPW 1211_ IARQM 1216_ ELHPD 1221_ KPPIL 1226_ LVAGK 1231_ DDMEM 1236_ CELNL 1241_ EETGL 1246_ TRKRG 1251_ AEILP 1256_ RQFEE 1261_ IWERC 1266_ GGIQY 1271_ LQNAI 1276_ ESRQA 1281_ RPTYA 1286_TAMLQ
1: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370)