Spermatogenesis-associated protein 2
1_MGKPS 6_ SMDTK 11_ FKDDL 16_ FRKYV 21_ QFHES 26_ KVDTT 31_ TSRQR 36_ PGSDE 41_ CLRVA 46_ ASTLL 51_ SLHKV 56_ DPFYR 61_ FRLIQ 66_ FYEVV 71_ ESSLR 76_ SLSSS 81_ SLRAL 86_ HGAFS 91_ MLETV 96_ GINLF 101_ LYPWK 106_ KEFRS 111_ IKTYT 116_ GPFVY 121_ YVKST 126_ LLEED 131_ IRAIL 136_ SCMGY 141_ TPELG 146_ TAYKL 151_ RELVE 156_ TLQVK 161_ MVSFE 166_ LFLAK 171_ VECEQ 176_ MLEIH 181_ SQVKD 186_ KGYSE 191_ LDIVS 196_ ERKSS 201_ AEDVR 206_ GCSDA 211_ LRRRA 216_ EGREH 221_ LTASM 226_ SRVAL 231_ QKSAS 236_ ERAAK 241_ DYYKP 246_ RVTKP 251_ SRSVD 256_ AYDSY 261_ WESRK 266_ PPLKA 271_ SLSLR 276_ KEPVA 281_ TDVGD 286_ DLKDE 291_ IIRPS 296_ PSLLT 301_ MASSP 306_ HGSPD 311_ VLPPA 316_ SPSNG 321_ PALLR 326_ GTYFS 331_ TQDDV 336_ DLYTD 341_ SEPRA 346_ TYRRQ 351_ DALRP 356_ DVWLL 361_ RNDAH 366_ SLYHK 371_ RSPPA 376_ KESAL 381_ SKCQS 386_ CGLSC 391_ SSSLC 396_ QRCDS 401_ LLTCP 406_ PASKP 411_ SAFPS 416_ KASTH 421_ DSLAH 426_ GASLR 431_ EKYPG 436_ QTQGL 441_ DRLPH 446_ LHSKS 451_ KPSTT 456_ PTSRC 461_ GFCNR 466_ PGATN 471_ TCTQC 476_ SKVSC 481_ DACLS 486_ AYHYD 491_ PCYKK 496_ SELHK 501_ FMPNN 506_ QLNYK 511_STQLS
1: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity)