Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
1_MAAAA 6_ GGGSC 11_ PGPGS 16_ ARGRF 21_ PGRPR 26_ GAGGG 31_ GGRGG 36_ RGNGA 41_ ERVRV 46_ ALRRG 51_ GGATG 56_ PGGAE 61_ PGEDT 66_ ALLRL 71_ LGLRR 76_ GLRRL 81_ RRLWA 86_ GPRVQ 91_ RGRGR 96_ GRGRG 101_ WGPSR 106_ GCVPE 111_ EESSD 116_ GESDE 121_ EEFQG 126_ FHSDE 131_ DVAPS 136_ SLRSA 141_ LRSQR 146_ GRAPR 151_ GRGRK 156_ HKTTP 161_ LPPPR 166_ LADVA 171_ PTPPK 176_ TPARK 181_ RGEEG 186_ TERMV 191_ QALTE 196_ LLRRA 201_ QAPQA 206_ PRSRA 211_ CEPST 216_ PRRSR 221_ GRPPG 226_ RPAGP 231_ CRRKQ 236_ QAVVV 241_ AEAAV 246_ TIPKP 251_ EPPPP 256_ VVPVK 261_ HQTGS 266_ WKCKE 271_ GPGPG 276_ PGTPR 281_ RGGQS 286_ SRGGR 291_ GGRGR 296_ GRGGG 301_ LPFVI 306_ KFVSR 311_ AKKVK 316_ MGQLS 321_ LGLES 326_ GQGQG 331_ QHEES 336_ WQDVP 341_ QRRVG 346_ SGQGG 351_ SPCWK 356_ KQEQK 361_ LDDEE 366_ EEKKE 371_ EEEKD 376_ KEGEE 381_ KEERA 386_ VAEEM 391_ MPAAE 396_ KEEAK 401_ LPPPP 406_ LTPPA 411_ PSPPP 416_ PLPPP 421_ STSPP 426_ PPLCP 431_ PPPPP 436_ VSPPP 441_ LPSPP 446_ PPPAQ 451_ EEQEE 456_ SPPPV 461_ VPATC 466_ SRKRG 471_ RPPLT 476_ PSQRA 481_ EREAA 486_ RAGPE 491_ GTSPP 496_ TPTPS 501_ TATGG 506_ PPEDS 511_ PTVAP 516_ KSTTF 521_ LKNIR 526_ QFIMP 531_ VVSAR 536_ SSRVI 541_ KTPRR 546_ FMDED 551_ PPKPP 556_ KVEVS 561_ PVLRP 566_ PITTS 571_ PPVPQ 576_ EPAPV 581_ PSPPR 586_ APTPP 591_ STPVP 596_ LPEKR 601_ RSILR 606_ EPTFR 611_ WTSLT 616_ RELPP 621_ PPPAP 626_ PPPPA 631_ PSPPP 636_ APATS 641_ SRRPL 646_ LLRAP 651_ QFTPS 656_ EAHLK 661_ IYESV 666_ LTPPP 671_ LGAPE 676_ APEPE 681_ PPPAD 686_ DSPAE 691_ PEPRA 696_ VGRTN 701_ HLSLP 706_ RFAPV 711_ VTTPV 716_ KAEVS 721_ PHGAP 726_ ALSNG 731_ PQTQA 736_ QLLQP 741_ LQALQ 746_ TQLLP 751_ QALPP 756_ PQPQL 761_ QPPPS 766_ PQQMP 771_ PLEKA 776_ RIAGV 781_ GSLPL 786_ SGVEE 791_ KMFSL 796_ LKRAK 801_ VQLFK 806_ IDQQQ 811_ QQKVA 816_ ASMPL 821_ SPGGQ 826_ MEEVA 831_ GAVKQ 836_ ISDRG 841_ PVRSE 846_ DESVE 851_ AKRER 856_ PSGPE 861_ SPVQG 866_ PRIKH 871_ VCRHA 876_ AVALG 881_ QARAM 886_ VPEDV 891_ PRLSA 896_ LPLRD 901_ RQDLA 906_ TEDTS 911_ SASET 916_ ESVPS 921_ RSRRG 926_ KVEAA 931_ GPGGE 936_ SEPTG 941_ SGGTL 946_ AHTPR 951_ RSLPS 956_ HHGKK 961_ MRMAR 966_ CGHCR 971_ GCLRV 976_ QDCGS 981_ CVNCL 986_ DKPKF 991_ GGPNT 996_ KKQCC 1001_ VYRKC 1006_ DKIEA 1011_ RKMER 1016_ LAKKG 1021_ RTIVK 1026_ TLLPW 1031_ DSDES 1036_ PEASP 1041_ GPPGP 1046_ RRGAG 1051_ AGGPR 1056_ EEVVA 1061_ HPGPE 1066_ EQDSL 1071_ LQRKS 1076_ ARRCV 1081_ KQRPS 1086_ YDIFE 1091_ DSDDS 1096_ EPGGP 1101_ PAPRR 1106_ RTPRE 1111_ NELPL 1116_ PEPEE 1121_ QSRPR 1126_ KPTLQ 1131_ PVLQL 1136_ KARRR 1141_ LDKDA 1146_ LAPGP 1151_ FASFP 1156_ NGWTG 1161_ KQKSP 1166_ DGVHR 1171_ VRVDF 1176_ KEDCD 1181_ LENVW 1186_ LMGGL 1191_ SVLTS 1196_ VPGGP 1201_ PMVCL 1206_ LCASK 1211_ GLHEL 1216_ VFCQV 1221_ CCDPF 1226_ HPFCL 1231_ EEAER 1236_ PLPQH 1241_ HDTWC 1246_ CRRCK 1251_ FCHVC 1256_ GRKGR 1261_ GSKHL 1266_ LECER 1271_ CRHAY 1276_ HPACL 1281_ GPSYP 1286_ TRATR 1291_ KRRHW 1296_ ICSAC 1301_ VRCKS 1306_ CGATP 1311_ GKNWD 1316_ VEWSG 1321_ DYSLC 1326_ PRCTQ 1331_ LYEKG 1336_ NYCPI 1341_ CTRCY 1346_ EDNDY 1351_ ESKMM 1356_ QCAQC 1361_ DHWVH 1366_ AKCEG 1371_ LSDED 1376_ YEILS 1381_ GLPDS 1386_ VLYTC 1391_ GPCAG 1396_ AAQPR 1401_ WREAL 1406_ SGALQ 1411_ GGLRQ 1416_ VLQGL 1421_ LSSKV 1426_ VGPLL 1431_ LCTQC 1436_ GPDGK 1441_ QLHPG 1446_ PCGLQ 1451_ AVSQR 1456_ FEDGH 1461_ YKSVH 1466_ SFMED 1471_ MVGIL 1476_ MRHSE 1481_ EGETP 1486_ DRRAG 1491_ GQMKG 1496_ LLLKL 1501_ LESAF 1506_ GWFDA 1511_ HDPKY 1516_ WRRST 1521_ RLPNG 1526_ VLPNA 1531_ VLPPS 1536_ LDHVY 1541_ AQWRQ 1546_ QEPET 1551_ PESGQ 1556_ PPGDP 1561_ SAAFQ 1566_ GKDPA 1571_ AFSHL 1576_ EDPRQ 1581_ CALCL 1586_ KYGDA 1591_ DSKEA 1596_ GRLLY 1601_ IGQNE 1606_ WTHVN 1611_ CAIWS 1616_ AEVFE 1621_ ENDGS 1626_ LKNVH 1631_ AAVAR 1636_ GRQMR 1641_ CELCL 1646_ KPGAT 1651_ VGCCL 1656_ SSCLS 1661_ NFHFM 1666_ CARAS 1671_ YCIFQ 1676_ DDKKV 1681_ FCQKH 1686_ TDLLD 1691_ GKEIV 1696_ NPDGF 1701_ DVLRR 1706_ VYVDF 1711_ EGINF 1716_ KRKFL 1721_ TGLEP 1726_ DAINV 1731_ LIGSI 1736_ RIDSL 1741_ GTLSD 1746_ LSDCE 1751_ GRLFP 1756_ IGYQC 1761_ SRLYW 1766_ STVDA 1771_ RRRCW 1776_ YRCRI 1781_ LEYRP 1786_ WGPRE 1791_ EPAHL 1796_ EAAEE 1801_ NQTIV 1806_ HSPAP 1811_ SSEPP 1816_ GGEDP 1821_ PLDTD 1826_ VLVPG 1831_ APERH 1836_ SPIQN 1841_ LDPPL 1846_ RPDSG 1851_ SAPPP 1856_ APRSF 1861_ SGARI 1866_ KVPNY 1871_ SPSRR 1876_ PLGGV 1881_ SFGPL 1886_ PSPGS 1891_ PSSLT 1896_ HHIPT 1901_ VGDPD 1906_ FPAPP 1911_ RRSRR 1916_ PSPLA 1921_ PRPPP 1926_ SRWAS 1931_ PPLKT 1936_ SPQLR 1941_ VPPPT 1946_ SVVTA 1951_ LTPTS 1956_ GELAP 1961_ PGPAP 1966_ SPPPP 1971_ EDLGP 1976_ DFEDM 1981_ EVVSG 1986_ LSAAD 1991_ LDFAA 1996_ SLLGT 2001_ EPFQE 2006_ EIVAA 2011_ GAMGS 2016_ SHGGP 2021_ GDSSE 2026_ EESSP 2031_ TSRYI 2036_ HFPVT 2041_ VVSAP 2046_ GLAPS 2051_ ATPGA 2056_ PRIEQ 2061_ LDGVD 2066_ DGTDS 2071_ EAEAV 2076_ QQPRG 2081_ QGTPP 2086_ SGPGV 2091_ VRAGV 2096_ LGAAG 2101_ DRARP 2106_ PEDLP 2111_ SEIVD 2116_ FVLKN 2121_ LGGPG 2126_ DGGAG 2131_ PREES 2136_ LPPAP 2141_ PLANG 2146_ SQPSQ 2151_ GLTAS 2156_ PADPT 2161_ RTFAW 2166_ LPGAP 2171_ GVRVL 2176_ SLGPA 2181_ PEPPK 2186_ PATSK 2191_ IILVN 2196_ KLGQV 2201_ FVKMA 2206_ GEGEP 2211_ VPPPV 2216_ KQPPL 2221_ PPTIS 2226_ PTAPT 2231_ SWTLP 2236_ PGPLL 2241_ GVLPV 2246_ VGVVR 2251_ PAPPP 2256_ PPPPL 2261_ TLVLS 2266_ SGPAS 2271_ PPRQA 2276_ IRVKR 2281_ VSTFS 2286_ GRSPP 2291_ APPPY 2296_ KAPRL 2301_ DEDGE 2306_ ASEDT 2311_ PQVPG 2316_ LGSGG 2321_ FSRVR 2326_ MKTPT 2331_ VRGVL 2336_ DLDRP 2341_ GEPAG 2346_ EESPG 2351_ PLQER 2356_ SPLLP 2361_ LPEDG 2366_ PPQVP 2371_ DGPPD 2376_ LLLES 2381_ QWHHY 2386_ SGEAS 2391_ SSEEE 2396_ PPSPD 2401_ DKENQ 2406_ APKRT 2411_ GPHLR 2416_ FEISS 2421_ EDGFS 2426_ VEAES 2431_ LEGAW 2436_ RTLIE 2441_ KVQEA 2446_ RGHAR 2451_ LRHLS 2456_ FSGMS 2461_ GARLL 2466_ GIHHD 2471_ AVIFL 2476_ AEQLP 2481_ GAQRC 2486_ QHYKF 2491_ RYHQQ 2496_ GEGQE 2501_ EPPLN 2506_ PHGAA 2511_ RAEVY 2516_ LRKCT 2521_ FDMFN 2526_ FLASQ 2531_ HRVLP 2536_ EGATC 2541_ DEEED 2546_ EVQLR 2551_ STRRA 2556_ TSLEL 2561_ PMAMR 2566_ FRHLK 2571_ KTSKE 2576_ AVGVY 2581_ RSAIH 2586_ GRGLF 2591_ CKRNI 2596_ DAGEM 2601_ VIEYS 2606_ GIVIR 2611_ SVLTD 2616_ KREKF 2621_ YDGKG 2626_ IGCYM 2631_ FRMDD 2636_ FDVVD 2641_ ATMHG 2646_ NAARF 2651_ INHSC 2656_ EPNCF 2661_ SRVIH 2666_ VEGQK 2671_ HIVIF 2676_ ALRRI 2681_ LRGEE 2686_ LTYDY 2691_ KFPIE 2696_ DASNK 2701_ LPCNC 2706_GAKRC
1: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity)