Synaptopodin-2 (Genethonin-2) (Myopodin)
1_MGTGD 6_ FICIS 11_ MTGGA 16_ PWGFR 21_ LQGGK 26_ EQKQP 31_ LQVAK 36_ IRNQS 41_ KASGS 46_ GLCEG 51_ DEVVS 56_ INGNP 61_ CADLT 66_ YPEVI 71_ KLMES 76_ ITDSL 81_ QMLIK 86_ RPSSG 91_ ISEAL 96_ ISENE 101_ NKNLE 106_ HLTHG 111_ GYVES 116_ TTLQI 121_ RPATK 126_ TQCTE 131_ FFLAP 136_ VKTEV 141_ PLAEN 146_ QRSGP 151_ DCAGS 156_ LKEET 161_ GPSYQ 166_ RAPQM 171_ PDSQR 176_ GRVAE 181_ ELILR 186_ EKVEA 191_ VQPGP 196_ VVELQ 201_ LSLSQ 206_ ERHKG 211_ ASGPL 216_ VALPG 221_ AEKSK 226_ SPDPD 231_ PNLSH 236_ DRIVH 241_ INSIP 246_ TNEKA 251_ DPFLR 256_ SSKII 261_ QISSG 266_ RELRV 271_ IQESE 276_ AGDAG 281_ LPRVE 286_ VILDC 291_ SDRQK 296_ TEGCR 301_ LQAGK 306_ ECVDS 311_ PVEGG 316_ QSEAP 321_ PSLVS 326_ FAVSS 331_ EGTEQ 336_ GEDPR 341_ SEKDH 346_ SRPHK 351_ HRARH 356_ ARLRR 361_ SESLS 366_ EKQVK 371_ EAKSK 376_ CKSIA 381_ LLLTD 386_ APNPN 391_ SKGVL 396_ MFKKR 401_ RRRAR 406_ KYTLV 411_ SYGTG 416_ ELERE 421_ ADEEE 426_ EGDKE 431_ DTCEV 436_ AFLGA 441_ SESEV 446_ DEELL 451_ SDVDD 456_ NTQVV 461_ NFDWD 466_ SGLVD 471_ IEKKL 476_ NRGDK 481_ MEMLP 486_ DTTGK 491_ GALMF 496_ AKRRE 501_ RMDQI 506_ TAQKE 511_ EDKVG 516_ GTPSR 521_ EQDAA 526_ QTDGL 531_ RTTTS 536_ YQRKE 541_ EESVR 546_ TQSSV 551_ SKSYI 556_ EVSHG 561_ LGHVP 566_ QQNGF 571_ SGTSE 576_ TANIQ 581_ RMVPM 586_ NRTAK 591_ PFPGS 596_ VNQPA 601_ TPFSP 606_ TRNMT 611_ SPIAD 616_ FPAPP 621_ PYSAV 626_ TPPPD 631_ AFSRG 636_ VSSPI 641_ AGPAQ 646_ PPPWP 651_ QPAPW 656_ SQPAF 661_ YDSSE 666_ RIASR 671_ DERIS 676_ VPAKR 681_ TGILQ 686_ EAKRR 691_ STTKP 696_ MFTFK 701_ EPKVS 706_ PNPEL 711_ LSLLQ 716_ NSEGK 721_ RGTGA 726_ GGDSG 731_ PEEDY 736_ LSLGA 741_ EACNF 746_ MQSSS 751_ AKQKT 756_ PPPVA 761_ PKPAV 766_ KSSSS 771_ QPVTP 776_ VSPVW 781_ SPGVA 786_ PTQPP 791_ AFPTS 796_ NPSKG 801_ TVVSS 806_ IKIAQ 811_ PSYPP 816_ ARPAS 821_ TLNVA 826_ GPFKG 831_ PQAAV 836_ ASQNY 841_ TPKPT 846_ VSTPT 851_ VNAVQ 856_ PGAVG 861_ PSNEL 866_ PGMSG 871_ RGAQL 876_ FAKRQ 881_ SRMEK 886_ YVVDS 891_ DTVQA 896_ HAARA 901_ QSPTP 906_ SLPAS 911_ WKYSS 916_ NVRAP 921_ PPVAY 926_ NPIHS 931_ PSYPL 936_ AALKS 941_ QPSAA 946_ QPSKM 951_ GKKKG 956_ KKPLN 961_ ALDVM 966_ KHQPY 971_ QLNAS 976_ LFTFQ 981_ PPDAK 986_ DGLPQ 991_ KSSVK 996_ VNSAL 1001_ AMKQA 1006_ LPPRP 1011_ VNAAS 1016_ PTNVQ 1021_ ASSVY 1026_ SVPAY 1031_ TSPPS 1036_ FFAEA 1041_ SSPVS 1046_ ASPVP 1051_ VGIPT 1056_ SPKQE 1061_ SASSS 1066_ YFVAP 1071_ RPKFS 1076_ AKKSG 1081_ VTIQV 1086_WKPSV
1: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336)
2: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body
3: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers
4: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles
5: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers
6: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro