Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
1_MAESG 6_ ESGGP 11_ PGSQD 16_ SAAGA 21_ EGAGA 26_ PAAAA 31_ SAEPK 36_ IMKVT 41_ VKTPK 46_ EKEEF 51_ AVPEN 56_ SSVQQ 61_ FKEEI 66_ SKRFK 71_ SHTDQ 76_ LVLIF 81_ AGKIL 86_ KDQDT 91_ LSQHG 96_ IHDGL 101_ TVHLV 106_ IKTQN 111_ RPQDH 116_ SAQQT 121_ NTAGS 126_ NVTTS 131_ STPNS 136_ NSTSG 141_ SATSN 146_ PFGLG 151_ GLGGL 156_ AGLSS 161_ LGLNT 166_ TNFSE 171_ LQSQM 176_ QRQLL 181_ SNPEM 186_ MVQIM 191_ ENPFV 196_ QSMLS 201_ NPDLM 206_ RQLIM 211_ ANPQM 216_ QQLIQ 221_ RNPEI 226_ SHMLN 231_ NPDIM 236_ RQTLE 241_ LARNP 246_ AMMQE 251_ MMRNQ 256_ DRALS 261_ NLESI 266_ PGGYN 271_ ALRRM 276_ YTDIQ 281_ EPMLS 286_ AAQEQ 291_ FGGNP 296_ FASLV 301_ SNTSS 306_ GEGSQ 311_ PSRTE 316_ NRDPL 321_ PNPWA 326_ PQTSQ 331_ SSSAS 336_ SGTAS 341_ TVGGT 346_ TGSTA 351_ SGTSG 356_ QSTTA 361_ PNLVP 366_ GVGAS 371_ MFNTP 376_ GMQSL 381_ LQQIT 386_ ENPQL 391_ MQNML 396_ SAPYM 401_ RSMMQ 406_ SLSQN 411_ PDLAA 416_ QMMLN 421_ NPLFA 426_ GNPQL 431_ QEQMR 436_ QQLPT 441_ FLQQM 446_ QNPDT 451_ LSAMS 456_ NPRAM 461_ QALLQ 466_ IQQGL 471_ QTLAT 476_ EAPGL 481_ IPGFT 486_ PGLGA 491_ LGSTG 496_ GSSGT 501_ NGSNA 506_ TPSEN 511_ TSPTA 516_ GTTEP 521_ GHQQF 526_ IQQML 531_ QALAG 536_ VNPQL 541_ QNPEV 546_ RFQQQ 551_ LEQLS 556_ AMGFL 561_ NREAN 566_ LQALI 571_ ATGGD 576_ INAAI 581_ERLLG
1: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:18307982, PubMed:19822669). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (PubMed:22233804)
2: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716)
3: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress
4: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716)