Suppressor of fused homolog (SUFUH)
1_MAELR 6_ PSGAP 11_ GPTAP 16_ PAPGP 21_ TAPPA 26_ FASLF 31_ PPGLH 36_ AIYGE 41_ CRRLY 46_ PDQPN 51_ PLQVT 56_ AIVKY 61_ WLGGP 66_ DPLDY 71_ VSMYR 76_ NVGSP 81_ SANIP 86_ EHWHY 91_ ISFGL 96_ SDLYG 101_ DNRVH 106_ EFTGT 111_ DGPSG 116_ FGFEL 121_ TFRLK 126_ RETGE 131_ SAPPT 136_ WPAEL 141_ MQGLA 146_ RYVFQ 151_ SENTF 156_ CSGDH 161_ VSWHS 166_ PLDNS 171_ ESRIQ 176_ HMLLT 181_ EDPQM 186_ QPVQT 191_ PFGVV 196_ TFLQI 201_ VGVCT 206_ EELHS 211_ AQQWN 216_ GQGIL 221_ ELLRT 226_ VPIAG 231_ GPWLI 236_ TDMRR 241_ GETIF 246_ EIDPH 251_ LQERV 256_ DKGIE 261_ TDGSN 266_ LSGVS 271_ AKCAW 276_ DDLSR 281_ PPEDD 286_ EDSRS 291_ ICIGT 296_ QPRRL 301_ SGKDT 306_ EQIRE 311_ TLRRG 316_ LEINS 321_ KPVLP 326_ PINPQ 331_ RQNGL 336_ AHDRA 341_ PSRKD 346_ SLESD 351_ SSTAI 356_ IPHEL 361_ IRTRQ 366_ LESVH 371_ LKFNQ 376_ ESGAL 381_ IPLCL 386_ RGRLL 391_ HGRHF 396_ TYKSI 401_ TGDMA 406_ ITFVS 411_ TGVEG 416_ AFATE 421_ EHPYA 426_ AHGPW 431_ LQILL 436_ TEEFV 441_ EKMLE 446_ DLEDL 451_ TSPEE 456_ FKLPK 461_ EYSWP 466_ EKKLK 471_ VSILP 476_DVVFD
1: Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:27234298, PubMed:28965847). Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24217340, PubMed:24311597). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24217340, PubMed:24311597). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:24311597, PubMed:28965847). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:24311597, PubMed:28965847). Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:24311597, PubMed:28965847). When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:24311597, PubMed:28965847). Required for normal embryonic development (By similarity). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity)