Ornithine decarboxylase antizyme 3 (AZ3) (ODC-Az 3)
1_MPCKR 6_ CRPSV 11_ YSLSY 16_ IKRGK 21_ TRNYL 26_ YPIWS 31_ PYAYY 36_ LYCYK 41_ YRITL 46_ REKML 51_ PRCYK 56_ SITYK 61_ EEEDL 66_ TLQPR 71_ SCLQC 76_ SESLV 81_ GLQEG 86_ KSTEQ 91_ GNHDQ 96_ LKELY 101_ SAGNL 106_ TVLAT 111_ DPLLH 116_ QDPVQ 121_ LDFHF 126_ RLTSQ 131_ TSAHW 136_ HGLLC 141_ DRRLF 146_ LDIPY 151_ QALDQ 156_ GNRES 161_ LTATL 166_ EYVEE 171_ KTNVD 176_ SVFVN 181_ FQNDR 186_ NDRGA 191_ LLRAF 196_ SYMGF 201_ EVVRP 206_ DHPAL 211_ PPLDN 216_ VIFMV 221_ YPLER 226_DVGHL
1: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity)