Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9)
1_MEVLR 6_ RSSVF 11_ AAEIM 16_ DAFDR 21_ SPTDK 26_ ELVAQ 31_ AKALG 36_ REYVH 41_ ARLLR 46_ AGLSW 51_ SAPER 56_ AAPVP 61_ GRLAE 66_ VCAVL 71_ LRLGD 76_ ELEMI 81_ RPSVY 86_ RNVAR 91_ QLHIS 96_ LQSEP 101_ VVTDA 106_ FLAVA 111_ GHIFS 116_ AGITW 121_ GKVVS 126_ LYAVA 131_ AGLAV 136_ DCVRQ 141_ AQPAM 146_ VHALV 151_ DCLGE 156_ FVRKT 161_ LATWL 166_ RRRGG 171_ WTDVL 176_ KCVVS 181_ TDPGL 186_ RSHWL 191_ VAALC 196_ SFGRF 201_ LKAAF 206_FVLLP
1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:15102863, PubMed:20673843, PubMed:27076518). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:15102863, PubMed:27076518). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155)
2: Pro-apoptotic molecule exerting its function through the mitochondrial pathway