Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Protein GIG47) (Secreted protein of unknown function) (SPUF protein)
1_MVGPA 6_ PRRRL 11_ RPLAA 16_ LALVL 21_ ALAPG 26_ LPTAR 31_ AGQTP 36_ RPAER 41_ GPPVR 46_ LFTEE 51_ ELARY 56_ GGEEE 61_ DQPIY 66_ LAVKG 71_ VVFDV 76_ TSGKE 81_ FYGRG 86_ APYNA 91_ LTGKD 96_ STRGV 101_ AKMSL 106_ DPADL 111_ THDTT 116_ GLTAK 121_ ELEAL 126_ DEVFT 131_ KVYKA 136_ KYPIV 141_ GYTAR 146_ RILNE 151_ DGSPN 156_ LDFKP 161_ EDQPH 166_FDIKD
1: Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Also acts as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity)