Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B)
1_MGQEF 6_ SWEEA 11_ EAAGE 16_ IDVAE 21_ LQEWY 26_ KKFVM 31_ ECPSG 36_ TLFMH 41_ EFKRF 46_ FKVTD 51_ DEEAS 56_ QYVEG 61_ MFRAF 66_ DKNGD 71_ NTIDF 76_ LEYVA 81_ ALNLV 86_ LRGTL 91_ EHKLK 96_ WTFKI 101_ YDKDG 106_ NGCID 111_ RLELL 116_ NIVEG 121_ IYQLK 126_ KACRR 131_ ELQTE 136_ QGQLL 141_ TPEEV 146_ VDRIF 151_ LLVDE 156_ NGDGQ 161_ LSLNE 166_ FVEGA 171_ RRDKW 176_ VMKML 181_ QMDMN 186_ PSSWL 191_AQQRR
1: Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity)