Nucleolar protein 7 (Nucleolar protein of 27 kDa)
1_MVQLR 6_ PRASR 11_ APASA 16_ EAMVD 21_ EGQLA 26_ SEEEE 31_ AEHGL 36_ LLGQP 41_ SSGAA 46_ AEPLE 51_ EDEEG 56_ DDEFD 61_ DEAPE 66_ ELTFA 71_ SAQAE 76_ AREEE 81_ RRVRE 86_ TVRRD 91_ KTLLK 96_ EKRKR 101_ REELF 106_ IEQKK 111_ RKLLP 116_ DTILE 121_ KLTTA 126_ SQTNI 131_ KKSPG 136_ KVKEV 141_ NLQKK 146_ NEDCE 151_ KGNDS 156_ KKVKV 161_ QKVQS 166_ VSQNK 171_ SYLAV 176_ RLKDQ 181_ DLRDS 186_ RQQAA 191_ QAFIH 196_ NSLYG 201_ PGTNR 206_ TTVNK 211_ FLSLA 216_ NKRLP 221_ VKRAA 226_ VQFLN 231_ NAWGI 236_ QKKQN 241_ AKRFK 246_ RRWMV 251_RKMKT
1: Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing (PubMed:34516797, PubMed:37246770). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). This subunit is required for processing of the 5'-external transcribed spacer sequence (5'ETS) of the primary transcript pre-rRNA to yield the 18S rRNA (PubMed:37246770). Also plays a role in maintaining early pre-rRNA levels, either by assisting in its transcription or stability (PubMed:37246770)