Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48)
1_MKKVP 6_ IKPEQ 11_ PEKLR 16_ AFNIS 21_ THSFS 26_ LHWSL 31_ PSGHV 36_ ERYQV 41_ DLVPD 46_ SGFVT 51_ IRDLG 56_ GGEYQ 61_ VDVSN 66_ VVPGT 71_ RYDIT 76_ ISSIS 81_ TTYTS 86_ PVTRI 91_ VTTNV 96_ TKPGP 101_ PVFLA 106_ GERVG 111_ SAGIL 116_ LSWNT 121_ PPNPN 126_ GRIIS 131_ YIVKY 136_ KEVCP 141_ WMQTV 146_ YTQVR 151_ SKPDS 156_ LEVLL 161_ TNLNP 166_ GTTYE 171_ IKVAA 176_ ENSAG 181_ IGVFS 186_ DPFLF 191_ QTAES 196_ APGKV 201_ VNLTV 206_ EAYNA 211_ SAVKL 216_ IWYLP 221_ RQPNG 226_ KITSF 231_ KISVK 236_ HARSG 241_ IVVKD 246_ VSIRV 251_ EDILT 256_ GKLPE 261_ CNENS 266_ ESFLW 271_ STASP 276_ SPTLG 281_ RVTPP 286_ SRTTH 291_ SSSTL 296_ TQNEI 301_ SSVWK 306_ EPISF 311_ VVTHL 316_ RPYTT 321_ YLFEV 326_ SAVTT 331_ EAGYI 336_ DSTIV 341_ RTPES 346_ VPEGP 351_ PQNCV 356_ TGNIT 361_ GKSFS 366_ ILWDP 371_ PTIVT 376_ GKFSY 381_ RVELY 386_ GPSGR 391_ ILDNS 396_ TKDLK 401_ FAFTN 406_ LTPFT 411_ MYDVY 416_ IAAET 421_ SAGTG 426_ PKSNI 431_ SVFTP 436_ PDVPG 441_ AVFDL 446_ QLAEV 451_ ESTQV 456_ RITWK 461_ KPRQP 466_ NGIIN 471_ QYRVK 476_ VLVPE 481_ TGIIL 486_ ENTLL 491_ TGNNE 496_ YINDP 501_ MAPEI 506_ VNIVE 511_ PMVGL 516_ YEGSA 521_ EMSSD 526_ LHSLA 531_ TFIYN 536_ SHPDK 541_ NFPAR 546_ NRAED 551_ QTSPV 556_ VTTRN 561_ QYITD 566_ IAAEQ 571_ LSYVI 576_ RRLVP 581_ FTEHM 586_ ISVSA 591_ FTIMG 596_ EGPPT 601_ VLSVR 606_ TRQQV 611_ PSSIK 616_ IINYK 621_ NISSS 626_ SILLY 631_ WDPPE 636_ YPNGK 641_ ITHYT 646_ IYAME 651_ LDTNR 656_ AFQIT 661_ TIDNS 666_ FLITG 671_ LKKYT 676_ KYKMR 681_ VAAST 686_ HVGES 691_ SLSEE 696_ NDIFV 701_ RTSED 706_ EPESS 711_ PQDVE 716_ VIDVT 721_ ADEIR 726_ LKWSP 731_ PEKPN 736_ GIIIA 741_ YEVLY 746_ KNIDT 751_ LYMKN 756_ TSTTD 761_ IILRN 766_ LRPHT 771_ LYNIS 776_ VRSYT 781_ RFGHG 786_ NQVSS 791_ LLSVR 796_ TSETV 801_ PDSAP 806_ ENITY 811_ KNISS 816_ GEIEL 821_ SFLPP 826_ SSPNG 831_ IIKKY 836_ TIYLK 841_ RSNGN 846_ EERTI 851_ NTTSL 856_ TQNIK 861_ VLKKY 866_ TQYII 871_ EVSAS 876_ TLKGE 881_ GVRSA 886_ PISIL 891_ TEEDA 896_ PDSPP 901_ QDFSV 906_ KQLSG 911_ VTVKL 916_ SWQPP 921_ LEPNG 926_ IILYY 931_ TVYVW 936_ NRSSL 941_ KTINV 946_ TETSL 951_ ELSDL 956_ DYNVE 961_ YSAYV 966_ TASTR 971_ FGDGK 976_ TRSNI 981_ ISFQT 986_ PEGAP 991_ SDPPK 996_ DVYYA 1001_ NLSSS 1006_ SIILF 1011_ WTPPS 1016_ KPNGI 1021_ IQYYS 1026_ VYYRN 1031_ TSGTF 1036_ MQNFT 1041_ LHEVT 1046_ NDFDN 1051_ MTVST 1056_ IIDKL 1061_ TIFSY 1066_ YTFWL 1071_ TASTS 1076_ VGNGN 1081_ KSSDI 1086_ IEVYT 1091_ DQDIP 1096_ EGFVG 1101_ NLTYE 1106_ SISST 1111_ AINVS 1116_ WVPPA 1121_ QPNGL 1126_ VFYYV 1131_ SLILQ 1136_ QTPRH 1141_ VRPPL 1146_ VTYER 1151_ SIYFD 1156_ NLEKY 1161_ TDYIL 1166_ KITPS 1171_ TEKGF 1176_ SDTYT 1181_ AQLYI 1186_ KTEED 1191_ VPETS 1196_ PIINT 1201_ FKNLS 1206_ STSVL 1211_ LSWDP 1216_ PVKPN 1221_ GAIIS 1226_ YDLTL 1231_ QGPNE 1236_ NYSFI 1241_ TSDNY 1246_ IILEE 1251_ LSPFT 1256_ LYSFF 1261_ AAART 1266_ RKGLG 1271_ PSSIL 1276_ FFYTD 1281_ ESVPL 1286_ APPQN 1291_ LTLIN 1296_ CTSDF 1301_ VWLKW 1306_ SPSPL 1311_ PGGIV 1316_ KVYSF 1321_ KIHEH 1326_ ETDTI 1331_ YYKNI 1336_ SGFKT 1341_ EAKLV 1346_ GLEPV 1351_ STYSI 1356_ RVSAF 1361_ TKVGN 1366_ GNQFS 1371_ NVVKF 1376_ TTQES 1381_ VPDVV 1386_ QNMQC 1391_ MATSW 1396_ QSVLV 1401_ KWDPP 1406_ KKANG 1411_ IITQY 1416_ MVTVE 1421_ RNSTK 1426_ VSPQD 1431_ HMYTF 1436_ IKLLA 1441_ NTSYV 1446_ FKVRA 1451_ STSAG 1456_ EGDES 1461_ TCHVS 1466_ TLPET 1471_ VPSVP 1476_ TNIAF 1481_ SDVQS 1486_ TSATL 1491_ TWIRP 1496_ DTILG 1501_ YFQNY 1506_ KITTQ 1511_ LRAQK 1516_ CKEWE 1521_ SEECV 1526_ EYQKI 1531_ QYLYE 1536_ AHLTE 1541_ ETVYG 1546_ LKKFR 1551_ WYRFQ 1556_ VAAST 1561_ NAGYG 1566_ NASNW 1571_ ISTKT 1576_ LPGPP 1581_ DGPPE 1586_ NVHVV 1591_ ATSPF 1596_ SISIS 1601_ WSEPA 1606_ VITGP 1611_ TCYLI 1616_ DVKSV 1621_ DNDEF 1626_ NISFI 1631_ KSNEE 1636_ NKTIE 1641_ IKDLE 1646_ IFTRY 1651_ SVVIT 1656_ AFTGN 1661_ ISAAY 1666_ VEGKS 1671_ SAEMI 1676_ VTTLE 1681_ SAPKD 1686_ PPNNM 1691_ TFQKI 1696_ PDEVT 1701_ KFQLT 1706_ FLPPS 1711_ QPNGN 1716_ IQVYQ 1721_ ALVYR 1726_ EDDPT 1731_ AVQIH 1736_ NLSII 1741_ QKTNT 1746_ FVIAM 1751_ LEGLK 1756_ GGHTY 1761_ NISVY 1766_ AVNSA 1771_ GAGPK 1776_ VPMRI 1781_ TMDIK 1786_ APARP 1791_ KTKPT 1796_ PIYDA 1801_ TGKLL 1806_ VTSTT 1811_ ITIRM 1816_ PICYY 1821_ SDDHG 1826_ PIKNV 1831_ QVLVT 1836_ ETGAQ 1841_ HDGNV 1846_ TKWYD 1851_ AYFNK 1856_ ARPYF 1861_ TNEGF 1866_ PNPPC 1871_ TEGKT 1876_ KFSGN 1881_ EEIYI 1886_ IGADN 1891_ ACMIP 1896_ GNEDK 1901_ ICNGP 1906_ LKPKK 1911_ QYLFK 1916_ FRATN 1921_ IMGQF 1926_ TDSDY 1931_ SDPVK 1936_ TLGEG 1941_ LSERT 1946_ VEIIL 1951_ SVTLC 1956_ ILSII 1961_ LLGTA 1966_ IFAFA 1971_ RIRQK 1976_ QKEGG 1981_ TYSPQ 1986_ DAEII 1991_ DTKLK 1996_ LDQLI 2001_ TVADL 2006_ ELKDE 2011_ RLTRP 2016_ ISKKS 2021_ FLQHV 2026_ EELCT 2031_ NNNLK 2036_ FQEEF 2041_ SELPK 2046_ FLQDL 2051_ SSTDA 2056_ DLPWN 2061_ RAKNR 2066_ FPNIK 2071_ PYNNN 2076_ RVKLI 2081_ ADASV 2086_ PGSDY 2091_ INASY 2096_ ISGYL 2101_ CPNEF 2106_ IATQG 2111_ PLPGT 2116_ VGDFW 2121_ RMVWE 2126_ TRAKT 2131_ LVMLT 2136_ QCFEK 2141_ GRIRC 2146_ HQYWP 2151_ EDNKP 2156_ VTVFG 2161_ DIVIT 2166_ KLMED 2171_ VQIDW 2176_ TIRDL 2181_ KIERH 2186_ GDCMT 2191_ VRQCN 2196_ FTAWP 2201_ EHGVP 2206_ ENSAP 2211_ LIHFV 2216_ KLVRA 2221_ SRAHD 2226_ TTPMI 2231_ VHCSA 2236_ GVGRT 2241_ GVFIA 2246_ LDHLT 2251_ QHIND 2256_ HDFVD 2261_ IYGLV 2266_ AELRS 2271_ ERMCM 2276_ VQNLA 2281_ QYIFL 2286_ HQCIL 2291_ DLLSN 2296_ KGSNQ 2301_ PICFV 2306_ NYSAL 2311_ QKMDS 2316_ LDAME 2321_ GDVEL 2326_EWEET
1: Dephosphorylates phosphatidylinositol phosphates, such as phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,5-diphosphates, with preference for PIP3 (PubMed:23897475). Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring (PubMed:23897475). Has low tyrosine-protein phosphatase activity in vitro; however, the relevance of such activity in vivo is unclear (By similarity). Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by regulating the levels of PIP3 in MSCs and preadipocyte cells (PubMed:19351528). Required for hair bundle maturation, a process that enables hair cells to detect and transmit sound and balance signals effectively, therefore affecting auditory function (PubMed:20472657, PubMed:29309402). May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles (By similarity)