Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12)
1_MSMRS 6_ PISAQ 11_ LALDG 16_ VGTMV 21_ NCTIK 26_ SEEKK 31_ EPCHE 36_ APQGS 41_ ATAAE 46_ PQPGD 51_ PARAS 56_ QDSAD 61_ PQAPA 66_ QGNFR 71_ GSWDC 76_ SSPEG 81_ NGSPE 86_ PKRPG 91_ VSEAA 96_ SGSQE 101_ KLDFN 106_ RNLKE 111_ VVPAI 116_ EKLLS 121_ SDWKE 126_ RFLGR 131_ NSMEA 136_ KDVKG 141_ TQESL 146_ AEKEL 151_ QLLVM 156_ IHQLS 161_ TLRDQ 166_ LLTAH 171_ SEQKN 176_ MAAML 181_ FEKQQ 186_ QQMEL 191_ ARQQQ 196_ EQIAK 201_ QQQQL 206_ IQQQH 211_ KINLL 216_ QQQIQ 221_ QVNMP 226_ YVMIP 231_ AFPPS 236_ HQPLP 241_ VTPDS 246_ QLALP 251_ IQPIP 256_ CKPVE 261_ YPLQL 266_ LHSPP 271_ APVVK 276_ RPGAM 281_ ATHHP 286_ LQEPS 291_ QPLNL 296_ TAKPK 301_ APELP 306_ NTSSS 311_ PSLKM 316_ SSCVP 321_ RPPSH 326_ GGPTR 331_ DLQSS 336_ PPSLP 341_ LGFLG 346_ EGDAV 351_ TKAIQ 356_ DARQL 361_ LHSHS 366_ GALDG 371_ SPNTP 376_ FRKDL 381_ ISLDS 386_ SPAKE 391_ RLEDG 396_ CVHPL 401_ EEAML 406_ SCDMD 411_ GSRHF 416_ PESRN 421_ SSHIK 426_ RPMNA 431_ FMVWA 436_ KDERR 441_ KILQA 446_ FPDMH 451_ NSSIS 456_ KILGS 461_ RWKSM 466_ TNQEK 471_ QPYYE 476_ EQARL 481_ SRQHL 486_ EKYPD 491_ YKYKP 496_ RPKRT 501_ CIVEG 506_ KRLRV 511_ GEYKA 516_ LMRTR 521_ RQDAR 526_ QSYVI 531_ PPQAG 536_ QVQMS 541_ SSDVL 546_ YPRAA 551_ GMPLA 556_ QPLVE 561_ HYVPR 566_ SLDPN 571_ MPVIV 576_ NTCSL 581_ REEGE 586_ GTDDR 591_ HSVAD 596_ GEMYR 601_ YSEDE 606_ DSEGE 611_ EKSDG 616_ELVVL
1: Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982)