Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
1_MVMEK 6_ PSPLL 11_ VGREF 16_ VRQYY 21_ TLLNK 26_ APEYL 31_ HRFYG 36_ RNSSY 41_ VHGGV 46_ DASGK 51_ PQEAV 56_ YGQND 61_ IHHKV 66_ LSLNF 71_ SECHT 76_ KIRHV 81_ DAHAT 86_ LSDGV 91_ VVQVM 96_ GLLSN 101_ SGQPE 106_ RKFMQ 111_ TFVLA 116_ PEGSV 121_ PNKFY 126_ VHNDM 131_ FRYED 136_ EVFGD 141_ SEPEL 146_ DEESE 151_ DEVEE 156_ EQEER 161_ QPSPE 166_ PVQEN 171_ ANSGY 176_ YEAHP 181_ VTNGI 186_ EEPLE 191_ ESSHE 196_ PEPEP 201_ ESETK 206_ TEELK 211_ PQVEE 216_ KNLEE 221_ LEEKS 226_ TTPPP 231_ AEPVS 236_ LPQEP 241_ PKAFS 246_ WASVT 251_ SKNLP 256_ PSGTV 261_ SSSGI 266_ PPHVK 271_ APVSQ 276_ PRVEA 281_ KPEVQ 286_ SQPPR 291_ VREQR 296_ PRERP 301_ GFPPR 306_ GPRPG 311_ RGDME 316_ QNDSD 321_ NRRII 326_ RYPDS 331_ HQLFV 336_ GNLPH 341_ DIDEN 346_ ELKEF 351_ FMSFG 356_ NVVEL 361_ RINTK 366_ GVGGK 371_ LPNFG 376_ FVVFD 381_ DSEPV 386_ QRILI 391_ AKPIM 396_ FRGEV 401_ RLNVE 406_ EKKTR 411_ AARER 416_ ETRGG 421_ GDDRR 426_ DIRRN 431_ DRGPG 436_ GPRGI 441_ VGGGM 446_ MRDRD 451_ GRGPP 456_ PRGGM 461_ AQKLG 466_ SGRGT 471_ GQMEG 476_RFTGQ
1: Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:35977029). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity)