A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2)
1_MLLGW 6_ ASLLL 11_ CAFRL 16_ PLAAV 21_ GPAAT 26_ PAQDK 31_ AGQPP 36_ TAAAA 41_ AQPRR 46_ RQGEE 51_ VQERA 56_ EPPGH 61_ PHPLA 66_ QRRRS 71_ KGLVQ 76_ NIDQL 81_ YSGGG 86_ KVGYL 91_ VYAGG 96_ RRFLL 101_ DLERD 106_ GSVGI 111_ AGFVP 116_ AGGGT 121_ SAPWR 126_ HRSHC 131_ FYRGT 136_ VDGSP 141_ RSLAV 146_ FDLCG 151_ GLDGF 156_ FAVKH 161_ ARYTL 166_ KPLLR 171_ GPWAE 176_ EEKGR 181_ VYGDG 186_ SARIL 191_ HVYTR 196_ EGFSF 201_ EALPP 206_ RASCE 211_ TPAST 216_ PEAHE 221_ HAPAH 226_ SNPSG 231_ RAALA 236_ SQLLD 241_ QSALS 246_ PAGGS 251_ GPQTW 256_ WRRRR 261_ RSISR 266_ ARQVE 271_ LLLVA 276_ DASMA 281_ RLYGR 286_ GLQHY 291_ LLTLA 296_ SIANR 301_ LYSHA 306_ SIENH 311_ IRLAV 316_ VKVVV 321_ LGDKD 326_ KSLEV 331_ SKNAA 336_ TTLKN 341_ FCKWQ 346_ HQHNQ 351_ LGDDH 356_ EEHYD 361_ AAILF 366_ TREDL 371_ CGHHS 376_ CDTLG 381_ MADVG 386_ TICSP 391_ ERSCA 396_ VIEDD 401_ GLHAA 406_ FTVAH 411_ EIGHL 416_ LGLSH 421_ DDSKF 426_ CEETF 431_ GSTED 436_ KRLMS 441_ SILTS 446_ IDASK 451_ PWSKC 456_ TSATI 461_ TEFLD 466_ DGHGN 471_ CLLDL 476_ PRKQI 481_ LGPEE 486_ LPGQT 491_ YDATQ 496_ QCNLT 501_ FGPEY 506_ SVCPG 511_ MDVCA 516_ RLWCA 521_ VVRQG 526_ QMVCL 531_ TKKLP 536_ AVEGT 541_ PCGKG 546_ RICLQ 551_ GKCVD 556_ KTKKK 561_ YYSTS 566_ SHGNW 571_ GSWGS 576_ WGQCS 581_ RSCGG 586_ GVQFA 591_ YRHCN 596_ NPAPR 601_ NNGRY 606_ CTGKR 611_ AIYRS 616_ CSLMP 621_ CPPNG 626_ KSFRH 631_ EQCEA 636_ KNGYQ 641_ SDAKG 646_ VKTFV 651_ EWVPK 656_ YAGVL 661_ PADVC 666_ KLTCR 671_ AKGTG 676_ YYVVF 681_ SPKVT 686_ DGTEC 691_ RLYSN 696_ SVCVR 701_ GKCVR 706_ TGCDG 711_ IIGSK 716_ LQYDK 721_ CGVCG 726_ GDNSS 731_ CTKIV 736_ GTFNK 741_ KSKGY 746_ TDVVR 751_ IPEGA 756_ THIKV 761_ RQFKA 766_ KDQTR 771_ FTAYL 776_ ALKKK 781_ NGEYL 786_ INGKY 791_ MISTS 796_ ETIID 801_ INGTV 806_ MNYSG 811_ WSHRD 816_ DFLHG 821_ MGYSA 826_ TKEIL 831_ IVQIL 836_ ATDPT 841_ KPLDV 846_ RYSFF 851_ VPKKS 856_ TPKVN 861_ SVTSH 866_ GSNKV 871_ GSHTS 876_ QPQWV 881_ TGPWL 886_ ACSRT 891_ CDTGW 896_ HTRTV 901_ QCQDG 906_ NRKLA 911_ KGCPL 916_ SQRPS 921_AFKQC
1: Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection