DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B)
1_MEKLG 6_ VEPEE 11_ EGGGD 16_ DDEED 21_ AEAWA 26_ MELAD 31_ VGAAA 36_ SSQGV 41_ HDQVL 46_ PTPNA 51_ SSRVI 56_ VHVDL 61_ DCFYA 66_ QVEMI 71_ SNPEL 76_ KDKPL 81_ GVQQK 86_ YLVVT 91_ CNYEA 96_ RKLGV 101_ KKLMN 106_ VRDAK 111_ EKCPQ 116_ LVLVN 121_ GEDLT 126_ RYREM 131_ SYKVT 136_ ELLEE 141_ FSPVV 146_ ERLGF 151_ DENFV 156_ DLTEM 161_ VEKRL 166_ QQLQS 171_ DELSA 176_ VTVSG 181_ HVYNN 186_ QSINL 191_ LDVLH 196_ IRLLV 201_ GSQIA 206_ AEMRE 211_ AMYNQ 216_ LGLTG 221_ CAGVA 226_ SNKLL 231_ AKLVS 236_ GVFKP 241_ NQQTV 246_ LLPES 251_ CQHLI 256_ HSLNH 261_ IKEIP 266_ GIGYK 271_ TAKCL 276_ EALGI 281_ NSVRD 286_ LQTFS 291_ PKILE 296_ KELGI 301_ SVAQR 306_ IQKLS 311_ FGEDN 316_ SPVIL 321_ SGPPQ 326_ SFSEE 331_ DSFKK 336_ CSSEV 341_ EAKNK 346_ IEELL 351_ ASLLN 356_ RVCQD 361_ GRKPH 366_ TVRLI 371_ IRRYS 376_ SEKHY 381_ GRESR 386_ QCPIP 391_ SHVIQ 396_ KLGTG 401_ NYDVM 406_ TPMVD 411_ ILMKL 416_ FRNMV 421_ NVKMP 426_ FHLTL 431_ LSVCF 436_ CNLKA 441_ LNTAK 446_ KGLID 451_ YYLMP 456_ SLSTT 461_ SRSGK 466_ HSFKM 471_ KDTHM 476_ EDFPK 481_ DKETN 486_ RDFLP 491_ SGRIE 496_ STRTR 501_ ESPLD 506_ TTNFS 511_ KEKDI 516_ NEFPL 521_ CSLPE 526_ GVDQE 531_ VFKQL 536_ PVDIQ 541_ EEILS 546_ GKSRE 551_ KFQGK 556_ GSVSC 561_ PLHAS 566_ RGVLS 571_ FFSKK 576_ QMQDI 581_ PINPR 586_ DHLSS 591_ SKQVS 596_ SVSPC 601_ EPGTS 606_ GFNSS 611_ SSSYM 616_ SSQKD 621_ YSYYL 626_ DNRLK 631_ DERIS 636_ QGPKE 641_ PQGFH 646_ FTNSN 651_ PAVSA 656_ FHSFP 661_ NLQSE 666_ QLFSR 671_ NHTTD 676_ SHKQT 681_ VATDS 686_ HEGLT 691_ ENREP 696_ DSVDE 701_ KITFP 706_ SDIDP 711_ QVFYE 716_ LPEAV 721_ QKELL 726_ AEWKR 731_AGSDF
1: Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunoglobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940)