Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)
1_MSVTY 6_ DDSVG 11_ VEVSS 16_ DSFWE 21_ VGNYK 26_ RTVKR 31_ IDDGH 36_ RLCSD 41_ LMNCL 46_ HERAR 51_ IEKAY 56_ AQQLT 61_ EWARR 66_ WRQLV 71_ EKGPQ 76_ YGTVE 81_ KAWMA 86_ FMSEA 91_ ERVSE 96_ LHLEV 101_ KASLM 106_ NDDFE 111_ KIKNW 116_ QKEAF 121_ HKQMM 126_ GGFKE 131_ TKEAE 136_ DGFRK 141_ AQKPW 146_ AKKLK 151_ EVEAA 156_ KKAHH 161_ AACKE 166_ EKLAI 171_ SREAN 176_ SKADP 181_ SLNPE 186_ QLKKL 191_ QDKIE 196_ KCKQD 201_ VLKTK 206_ EKYEK 211_ SLKEL 216_ DQGTP 221_ QYMEN 226_ MEQVF 231_ EQCQQ 236_ FEEKR 241_ LRFFR 246_ EVLLE 251_ VQKHL 256_ DLSNV 261_ AGYKA 266_ IYHDL 271_ EQSIR 276_ AADAV 281_ EDLRW 286_ FRANH 291_ GPGMA 296_ MNWPQ 301_ FEEWS 306_ ADLNR 311_ TLSRR 316_ EKKKA 321_ TDGVT 326_ LTGIN 331_ QTGDQ 336_ SLPSK 341_ PSSTL 346_ NVPSN 351_ PAQSA 356_ QSQSS 361_ YNPFE 366_ DEDDT 371_ GSTVS 376_ EKDDT 381_ KAKNV 386_ SSYEK 391_ TQSYP 396_ TDWSD 401_ DESNN 406_ PFSST 411_ DANGD 416_ SNPFD 421_ DDATS 426_ GTEVR 431_ VRALY 436_ DYEGQ 441_ EHDEL 446_ SFKAG 451_ DELTK 456_ MEDED 461_ EQGWC 466_ KGRLD 471_ NGQVG 476_ LYPAN 481_YVEAI
1: Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity)
2: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866)