Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL)
1_MCLSH 6_ LENMP 11_ LSHSR 16_ TQGAQ 21_ RSSWK 26_ LWLFC 31_ SIVML 36_ LFLCS 41_ FSWLI 46_ FIFLQ 51_ LETAK 56_ EPCMA 61_ KFGPL 66_ PSKWQ 71_ MASSE 76_ PPCVN 81_ KVSDW 86_ KLEIL 91_ QNGLY 96_ LIYGQ 101_ VAPNA 106_ NYNDV 111_ APFEV 116_ RLYKN 121_ KDMIQ 126_ TLTNK 131_ SKIQN 136_ VGGTY 141_ ELHVG 146_ DTIDL 151_ IFNSE 156_ HQVLK 161_ NNTYW 166_ GIILL 171_ANPQF
1: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity)