Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A)
1_MAAES 6_ GELIG 11_ ACEFM 16_ KDRLY 21_ FATLR 26_ NRPKS 31_ TVNTH 36_ YFSID 41_ EELVY 46_ ENFYA 51_ DFGPL 56_ NLAMV 61_ YRYCC 66_ KLNKK 71_ LKSYS 76_ LSRKK 81_ IVHYT 86_ CFDQR 91_ KRANA 96_ AFLIG 101_ AYAVI 106_ YLKKT 111_ PEEAY 116_ RALLS 121_ GSNPP 126_ YLPFR 131_ DASFG 136_ NCTYN 141_ LTILD 146_ CLQGI 151_ RKGLQ 156_ HGFFD 161_ FETFD 166_ VDEYE 171_ HYERV 176_ ENGDF 181_ NWIVP 186_ GKFLA 191_ FSGPH 196_ PKSKI 201_ ENGYP 206_ LHAPE 211_ AYFPY 216_ FKKHN 221_ VTAVV 226_ RLNKK 231_ IYEAK 236_ RFTDA 241_ GFEHY 246_ DLFFI 251_ DGSTP 256_ SDNIV 261_ RRFLN 266_ ICENT 271_ EGAIA 276_ VHCKA 281_ GLGRT 286_ GTLIA 291_ CYVMK 296_ HYRFT 301_ HAEII 306_ AWIRI 311_ CRPGS 316_ IIGPQ 321_ QHFLE 326_ EKQAS 331_ LWVQG 336_ DIFRS 341_ KLKNR 346_ PSSEG 351_ SINKI 356_ LSGLD 361_ DMSIG 366_ GNLSK 371_ TQNME 376_ RFGED 381_ NLEDD 386_ DVEMK 391_ NGITQ 396_ GDKLR 401_ ALKSQ 406_ RQPRT 411_ SPSCA 416_ FRSDD 421_ TKGHP 426_ RAVSQ 431_ PFRLS 436_ SSLQG 441_ SAVTL 446_ KTSKM 451_ ALSPS 456_ ATAKR 461_ INRTS 466_ LSSGA 471_ TVRSF 476_ SINSR 481_ LASSL 486_ GNLNA 491_ ATDDP 496_ ENKKT 501_ SSSSK 506_ AGFTA 511_ SPFTN 516_ LLNGS 521_ SQPTT 526_ RNYPE 531_ LNNNQ 536_ YNRSS 541_ NSNGG 546_ NLNSP 551_ PGPHS 556_ AKTEE 561_ HTTIL 566_ RPSYT 571_ GLSSS 576_ SARFL 581_ SRSIP 586_SLQSE
1: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958)