Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed]
1_MMEGL 6_ DDGPD 11_ FLSEE 16_ DRGLK 21_ AINVD 26_ LQSDA 31_ ALQVD 36_ ISDAL 41_ SERDK 46_ VKFTV 51_ HTKSS 56_ LPNFK 61_ QNEFS 66_ VVRQH 71_ EEFIW 76_ LHDSF 81_ VENED 86_ YAGYI 91_ IPPAP 96_ PRPDF 101_ DASRE 106_ KLQKL 111_ GEGEG 116_ SMTKE 121_ EFTKM 126_ KQELE 131_ AEYLA 136_ IFKKT 141_ VAMHE 146_ VFLCR 151_ VAAHP 156_ ILRRD 161_ LNFHV 166_ FLEYN 171_ QDLSV 176_ RGKNK 181_ KEKLE 186_ DFFKN 191_ MVKSA 196_ DGVIV 201_ SGVKD 206_ VDDFF 211_ EHERT 216_ FLLEY 221_ HNRVK 226_ DASAK 231_ SDRMT 236_ RSHKS 241_ AADDY 246_ NRIGS 251_ SLYAL 256_ GTQDS 261_ TDICK 266_ FFLKV 271_ SELFD 276_ KTRKI 281_ EARVS 286_ ADEDL 291_ KLSDL 296_ LKYYL 301_ RESQA 306_ AKDLL 311_ YRRSR 316_ SLVDY 321_ ENANK 326_ ALDKA 331_ RAKNK 336_ DVLQA 341_ ETSQQ 346_ LCCQK 351_ FEKIS 356_ ESAKQ 361_ ELIDF 366_ KTRRV 371_ AAFRK 376_ NLVEL 381_ AELEL 386_ KHAKG 391_ NLQLL 396_ QNCLA 401_VLNGD
1: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable)