Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1)
1_MLEAP 6_ GPSDG 11_ CELSN 16_ PSASR 21_ VSCAG 26_ QMLEV 31_ QPGLY 36_ FGGAA 41_ AVAEP 46_ DHLRE 51_ AGITA 56_ VLTVD 61_ SEEPS 66_ FKAGP 71_ GVEDL 76_ WRLFV 81_ PALDK 86_ PETDL 91_ LSHLD 96_ RCVAF 101_ IGQAR 106_ AEGRA 111_ VLVHC 116_ HAGVS 121_ RSVAI 126_ ITAFL 131_ MKTDQ 136_ LPFEK 141_ AYEKL 146_ QILKP 151_ EAKMN 156_ EGFEW 161_ QLKLY 166_ QAMGY 171_ EVDTS 176_ SAIYK 181_ QYRLQ 186_ KVTEK 191_ YPELQ 196_ NLPQE 201_ LFAVD 206_ PTTVS 211_ QGLKD 216_ EVLYK 221_ CRKCR 226_ RSLFR 231_ SSSIL 236_ DHREG 241_ SGPIA 246_ FAHKR 251_ MTPSS 256_ MLTTG 261_ RQAQC 266_ TSYFI 271_ EPVQW 276_ MESAL 281_ LGVMD 286_ GQLLC 291_ PKCSA 296_ KLGSF 301_ NWYGE 306_ QCSCG 311_ RWITP 316_ AFQIH 321_ KNRVD 326_ EMKIL 331_PVLGS
1: Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476)