Inhibitor of growth protein 4 (p29ING4)
1_MAAGM 6_ YLEHY 11_ LDSIE 16_ NLPFE 21_ LQRNF 26_ QLMRD 31_ LDQRT 36_ EDLKA 41_ EIDKL 46_ ATEYM 51_ SSARS 56_ LSSEE 61_ KLALL 66_ KQIQE 71_ AYGKC 76_ KEFGD 81_ DKVQL 86_ AMQTY 91_ EMVDK 96_ HIRRL 101_ DTDLA 106_ RFEAD 111_ LKEKQ 116_ IESSD 121_ YDSSS 126_ SKGKK 131_ KGRTQ 136_ KEKKA 141_ ARARS 146_ KGKNS 151_ DEEAP 156_ KTAQK 161_ KLKLV 166_ RTSPE 171_ YGMPS 176_ VTFGS 181_ VHPSD 186_ VLDMP 191_ VDPNE 196_ PTYCL 201_ CHQVS 206_ YGEMI 211_ GCDNP 216_ DCSIE 221_ WFHFA 226_ CVGLT 231_ TKPRG 236_ KWFCP 241_RCSQE
1: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)