Lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.99.9) (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase) (GM3 synthase) (Ganglioside GM3 synthase) (ST3Gal V) (ST3GalV) (Sialyltransferase 9)
1_MRTKA 6_ AGCAE 11_ RRPLQ 16_ PRTEA 21_ AAAPA 26_ GRAMP 31_ SEYTY 36_ VKLRS 41_ DCSRP 46_ SLQWY 51_ TRAQS 56_ KMRRP 61_ SLLLK 66_ DILKC 71_ TLLVF 76_ GVWIL 81_ YILKL 86_ NYTTE 91_ ECDMK 96_ KMHYV 101_ DPDHV 106_ KRAQK 111_ YAQQV 116_ LQKEC 121_ RPKFA 126_ KTSMA 131_ LLFEH 136_ RYSVD 141_ LLPFV 146_ QKAPK 151_ DSEAE 156_ SKYDP 161_ PFGFR 166_ KFSSK 171_ VQTLL 176_ ELLPE 181_ HDLPE 186_ HLKAK 191_ TCRRC 196_ VVIGS 201_ GGILH 206_ GLELG 211_ HTLNQ 216_ FDVVI 221_ RLNSA 226_ PVEGY 231_ SEHVG 236_ NKTTI 241_ RMTYP 246_ EGAPL 251_ SDLEY 256_ YSNDL 261_ FVAVL 266_ FKSVD 271_ FNWLQ 276_ AMVKK 281_ ETLPF 286_ WVRLF 291_ FWKQV 296_ AEKIP 301_ LQPKH 306_ FRILN 311_ PVIIK 316_ ETAFD 321_ ILQYS 326_ EPQSR 331_ FWGRD 336_ KNVPT 341_ IGVIA 346_ VVLAT 351_ HLCDE 356_ VSLAG 361_ FGYDL 366_ NQPRT 371_ PLHYF 376_ DSQCM 381_ AAMNF 386_ QTMHN 391_ VTTET 396_ KFLLK 401_ LVKEG 406_ VVKDL 411_SGGID
1: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis) (PubMed:16934889, PubMed:9822625). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer) (PubMed:16934889)