Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)
1_MATTK 6_ RVLYV 11_ GGLAE 16_ EVDDK 21_ VLHAA 26_ FIPFG 31_ DITDI 36_ QIPLD 41_ YETEK 46_ HRGFA 51_ FVEFE 56_ LAEDA 61_ AAAID 66_ NMNES 71_ ELFGR 76_ TIRVN 81_ LAKPM 86_ RIKEG 91_ SSRPV 96_ WSDDD 101_ WLKKF 106_ SGKTL 111_ EENKE 116_ EEGSE 121_ PPKAE 126_ TQEGE 131_ PIAKK 136_ ARSNP 141_ QVYMD 146_ IKIGN 151_ KPAGR 156_ IQMLL 161_ RSDVV 166_ PMTAE 171_ NFRCL 176_ CTHEK 181_ GFGFK 186_ GSSFH 191_ RIIPQ 196_ FMCQG 201_ GDFTN 206_ HNGTG 211_ GKSIY 216_ GKKFD 221_ DENFI 226_ LKHTG 231_ PGLLS 236_ MANSG 241_ PNTNG 246_ SQFFL 251_ TCDKT 256_ DWLDG 261_ KHVVF 266_ GEVTE 271_ GLDVL 276_ RQIEA 281_ QGSKD 286_ GKPKQ 291_ KVIIA 296_DCGEY
1: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:18258190, PubMed:20460131, PubMed:20677832, PubMed:8977107). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:18258190, PubMed:20460131, PubMed:8977107). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:18258190, PubMed:20541251, PubMed:20677832, PubMed:8977107). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20460131, PubMed:20541251, PubMed:20677832)