Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338)
1_MSSSN 6_ VEVFI 11_ PVSQG 16_ NTNGF 21_ PATAS 26_ NDLKA 31_ FTEGA 36_ VLSFH 41_ NICYR 46_ VKLKS 51_ GFLPC 56_ RKPVE 61_ KEILS 66_ NINGI 71_ MKPGL 76_ NAILG 81_ PTGGG 86_ KSSLL 91_ DVLAA 96_ RKDPS 101_ GLSGD 106_ VLING 111_ APRPA 116_ NFKCN 121_ SGYVV 126_ QDDVV 131_ MGTLT 136_ VRENL 141_ QFSAA 146_ LRLAT 151_ TMTNH 156_ EKNER 161_ INRVI 166_ QELGL 171_ DKVAD 176_ SKVGT 181_ QFIRG 186_ VSGGE 191_ RKRTS 196_ IGMEL 201_ ITDPS 206_ ILFLD 211_ EPTTG 216_ LDSST 221_ ANAVL 226_ LLLKR 231_ MSKQG 236_ RTIIF 241_ SIHQP 246_ RYSIF 251_ KLFDS 256_ LTLLA 261_ SGRLM 266_ FHGPA 271_ QEALG 276_ YFESA 281_ GYHCE 286_ AYNNP 291_ ADFFL 296_ DIING 301_ DSTAV 306_ ALNRE 311_ EDFKA 316_ TEIIE 321_ PSKQD 326_ KPLIE 331_ KLAEI 336_ YVNSS 341_ FYKET 346_ KAELH 351_ QLSGG 356_ EKKKK 361_ ITVFK 366_ EISYT 371_ TSFCH 376_ QLRWV 381_ SKRSF 386_ KNLLG 391_ NPQAS 396_ IAQII 401_ VTVVL 406_ GLVIG 411_ AIYFG 416_ LKNDS 421_ TGIQN 426_ RAGVL 431_ FFLTT 436_ NQCFS 441_ SVSAV 446_ ELFVV 451_ EKKLF 456_ IHEYI 461_ SGYYR 466_ VSSYF 471_ LGKLL 476_ SDLLP 481_ MRMLP 486_ SIIFT 491_ CIVYF 496_ MLGLK 501_ PKADA 506_ FFVMM 511_ FTLMM 516_ VAYSA 521_ SSMAL 526_ AIAAG 531_ QSVVS 536_ VATLL 541_ MTICF 546_ VFMMI 551_ FSGLL 556_ VNLTT 561_ IASWL 566_ SWLQY 571_ FSIPR 576_ YGFTA 581_ LQHNE 586_ FLGQN 591_ FCPGL 596_ NATGN 601_ NPCNY 606_ ATCTG 611_ EEYLV 616_ KQGID 621_ LSPWG 626_ LWKNH 631_ VALAC 636_ MIVIF 641_ LTIAY 646_LKLLF
1: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562, PubMed:36749388). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response