Probable dimethyladenosine transferase (EC 2.1.1.183) (DIM1 dimethyladenosine transferase 1 homolog) (DIM1 dimethyladenosine transferase 1-like) (Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (Probable 18S rRNA dimethylase) (Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase)
1_MPKVK 6_ SGAIG 11_ RRRGR 16_ QEQRR 21_ ELKSA 26_ GGLMF 31_ NTGIG 36_ QHILK 41_ NPLII 46_ NSIID 51_ KAALR 56_ PTDVV 61_ LEVGP 66_ GTGNM 71_ TVKLL 76_ EKAKK 81_ VVACE 86_ LDPRL 91_ VAELH 96_ KRVQG 101_ TPVAS 106_ KLQVL 111_ VGDVL 116_ KTDLP 121_ FFDTC 126_ VANLP 131_ YQISS 136_ PFVFK 141_ LLLHR 146_ PFFRC 151_ AILMF 156_ QREFA 161_ LRLVA 166_ KPGDK 171_ LYCRL 176_ SINTQ 181_ LLARV 186_ DHLMK 191_ VGKNN 196_ FRPPP 201_ KVESS 206_ VVRIE 211_ PKNPP 216_ PPINF 221_ QEWDG 226_ LVRIT 231_ FVRKN 236_ KTLSA 241_ AFKSS 246_ AVQQL 251_ LEKNY 256_ RIHCS 261_ VHNII 266_ IPEDF 271_ SIADK 276_ IQQIL 281_ TSTGF 286_ SDKRA 291_ RSMDI 296_ DDFIR 301_ LLHGF 306_NAEGI
1: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)