Protein timeless homolog (hTIM)
1_MDLHM 6_ MNCEL 11_ LATCS 16_ ALGYL 21_ EGDTY 26_ HKEPD 31_ CLESV 36_ KDLIR 41_ YLRHE 46_ DETRD 51_ VRQQL 56_ GAAQI 61_ LQSDL 66_ LPILT 71_ QHHQD 76_ KPLFD 81_ AVIRL 86_ MVNLT 91_ QPALL 96_ CFGNL 101_ PKEPS 106_ FRHHF 111_ LQVLT 116_ YLQAY 121_ KEAFA 126_ SEKAF 131_ GVLSE 136_ TLYEL 141_ LQLGW 146_ EERQE 151_ EDNLL 156_ IERIL 161_ LLVRN 166_ ILHVP 171_ ADLDQ 176_ EKKID 181_ DDASA 186_ HDQLL 191_ WAIHL 196_ SGLDD 201_ LLLFL 206_ ASSSA 211_ EEQWS 216_ LHVLE 221_ IVSLM 226_ FRDQN 231_ PEQLA 236_ GVGQG 241_ RLAQE 246_ RSADF 251_ AELEV 256_ LRQRE 261_ MAEKK 266_ TRALQ 271_ RGNRH 276_ SRFGG 281_ SYIVQ 286_ GLKSI 291_ GERDL 296_ IFHKG 301_ LHNLR 306_ NYSSD 311_ LGKQP 316_ KKVPK 321_ RRQAA 326_ RELSI 331_ QRRSA 336_ LNVRL 341_ FLRDF 346_ CSEFL 351_ ENCYN 356_ RLMGS 361_ VKDHL 366_ LREKA 371_ QQHDE 376_ TYYMW 381_ ALAFF 386_ MAFNR 391_ AASFR 396_ PGLVS 401_ ETLSV 406_ RTFHF 411_ IEQNL 416_ TNYYE 421_ MMLTD 426_ RKEAA 431_ SWARR 436_ MHLAL 441_ KAYQE 446_ LLATV 451_ NEMDI 456_ SPDEA 461_ VRESS 466_ RIIKN 471_ NIFYV 476_ MEYRE 481_ LFLAL 486_ FRKFD 491_ ERCQP 496_ RSFLR 501_ DLVET 506_ THLFL 511_ KMLER 516_ FCRSR 521_ GNLVV 526_ QNKQK 531_ KRRKK 536_ KKKVL 541_ DQAIV 546_ SGNVP 551_ SSPEE 556_ VEAVW 561_ PALAE 566_ QLQCC 571_ AQNSE 576_ LSMDS 581_ VVPFD 586_ AASEV 591_ PVEEQ 596_ RAEAM 601_ VRIQD 606_ CLLAG 611_ QAPQA 616_ LTLLR 621_ SAREV 626_ WPEGD 631_ VFGSQ 636_ DISPE 641_ EEIQL 646_ LKQIL 651_ SAPLP 656_ RQQGP 661_ EERGA 666_ EEEEE 671_ EEEEE 676_ EEELQ 681_ VVQVS 686_ EKEFN 691_ FLDYL 696_ KRFAC 701_ STVVR 706_ AYVLL 711_ LRSYQ 716_ QNSAH 721_ TNHCI 726_ VKMLH 731_ RLAHD 736_ LKMEA 741_ LLFQL 746_ SVFCL 751_ FNRLL 756_ SDPAA 761_ GAYKE 766_ LVTFA 771_ KYILG 776_ KFFAL 781_ AAVNQ 786_ KAFVE 791_ LLFWK 796_ NTAVV 801_ REMTE 806_ GYGSL 811_ DDRSS 816_ SRRAP 821_ TWSPE 826_ EEAHL 831_ RELYL 836_ ANKDV 841_ EGQDV 846_ VEAIL 851_ AHLNT 856_ VPRTR 861_ KQIIH 866_ HLVQM 871_ GLADS 876_ VKDFQ 881_ RKGTH 886_ IVLWT 891_ GDQEL 896_ ELQRL 901_ FEEFR 906_ DSDDV 911_ LGHIM 916_ KNITA 921_ KRSRA 926_ RIVDK 931_ LLALG 936_ LVAER 941_ RELYK 946_ KRQKK 951_ LASSI 956_ LPNGA 961_ ESLKD 966_ FCQED 971_ LEEEE 976_ NLPEE 981_ DSEEE 986_ EEGGS 991_ EAEQV 996_ QGSLV 1001_ LSNEN 1006_ LGQSL 1011_ HQEGF 1016_ SIPLL 1021_ WLQNC 1026_ LIRAA 1031_ DDREE 1036_ DGCSQ 1041_ AVPLV 1046_ PLTEE 1051_ NEEAM 1056_ ENEQF 1061_ QQLLR 1066_ KLGVR 1071_ PPASG 1076_ QETFW 1081_ RIPAK 1086_ LSPTQ 1091_ LRRAA 1096_ ASLSQ 1101_ PEEEQ 1106_ KLQPE 1111_ LQPKV 1116_ PGEQG 1121_ SDEEH 1126_ CKEHR 1131_ AQALR 1136_ ALLLA 1141_ HKKKA 1146_ GLASP 1151_ EEEDA 1156_ VGKEP 1161_ LKAAP 1166_ KKRQL 1171_ LDSDE 1176_ EQEED 1181_ EGRNR 1186_ APELG 1191_ APGIQ 1196_ KKKRY 1201_QIEDD
1: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity)