COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)
1_MASAL 6_ EQFVN 11_ SVRQL 16_ SAQGQ 21_ MTQLC 26_ ELINK 31_ SGELL 36_ AKNLS 41_ HLDTV 46_ LGALD 51_ VQEHS 56_ LGVLA 61_ VLFVK 66_ FSMPS 71_ VPDFE 76_ TLFSQ 81_ VQLFI 86_ STCNG 91_ EHIRY 96_ ATDTF 101_ AGLCH 106_ QLTNA 111_ LVERK 116_ QPLRG 121_ IGILK 126_ QAIDK 131_ MQMNT 136_ NQLTS 141_ IHADL 146_ CQLCL 151_ LAKCF 156_ KPALP 161_ YLDVD 166_ MMDIC 171_ KENGA 176_ YDAKH 181_ FLCYY 186_ YYGGM 191_ IYTGL 196_ KNFER 201_ ALYFY 206_ EQAIT 211_ TPAMA 216_ VSHIM 221_ LESYK 226_ KYILV 231_ SLILL 236_ GKVQQ 241_ LPKYT 246_ SQIVG 251_ RFIKP 256_ LSNAY 261_ HELAQ 266_ VYSTN 271_ NPSEL 276_ RNLVN 281_ KHSET 286_ FTRDN 291_ NMGLV 296_ KQCLS 301_ SLYKK 306_ NIQRL 311_ TKTFL 316_ TLSLQ 321_ DMASR 326_ VQLSG 331_ PQEAE 336_ KYVLH 341_ MIEDG 346_ EIFAS 351_ INQKD 356_ GMVSF 361_ HDNPE 366_ KYNNP 371_ AMLHN 376_ IDQEM 381_ LKCIE 386_ LDERL 391_ KAMDQ 396_ EITVN 401_ PQFVQ 406_ KSMGS 411_ QEDDS 416_GNKPS
1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively