Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)
1_MLRAP 6_ GCLLR 11_ TSVAP 16_ AAALA 21_ AALLS 26_ SLARC 31_ SLLEP 36_ RDPVA 41_ SSLSP 46_ YFGTK 51_ TRYED 56_ VNPVL 61_ LSGPE 66_ APWRD 71_ PELLE 76_ GTCTP 81_ VQLVA 86_ LIRHG 91_ TRYPT 96_ VKQIR 101_ KLRQL 106_ HGLLQ 111_ ARGSR 116_ DGGAS 121_ STGSR 126_ DLGAA 131_ LADWP 136_ LWYAD 141_ WMDGQ 146_ LVEKG 151_ RQDMR 156_ QLALR 161_ LASLF 166_ PALFS 171_ RENYG 176_ RLRLI 181_ TSSKH 186_ RCMDS 191_ SAAFL 196_ QGLWQ 201_ HYHPG 206_ LPPPD 211_ VADME 216_ FGPPT 221_ VNDKL 226_ MRFFD 231_ HCEKF 236_ LTEVE 241_ KNATA 246_ LYHVE 251_ AFKTG 256_ PEMQN 261_ ILKKV 266_ AATLQ 271_ VPVND 276_ LNADL 281_ IQVAF 286_ FTCSF 291_ DLAIK 296_ GVKSP 301_ WCDVF 306_ DIDDA 311_ KVLEY 316_ LNDLK 321_ QYWKR 326_ GYGYT 331_ INSRS 336_ SCTLF 341_ QDIFQ 346_ HLDKA 351_ VEQKQ 356_ RSQPI 361_ SSPVI 366_ LQFGH 371_ AETLL 376_ PLLSL 381_ MGYFK 386_ DKEPL 391_ TAYNY 396_ KKQMH 401_ RKFRS 406_ GLIVP 411_ YASNL 416_ IFVLY 421_ HCENA 426_ KTPKE 431_ QFRVQ 436_ MLLNE 441_ KVLPL 446_ AYSQE 451_ TVSFY 456_ EDLKN 461_ HYKDI 466_ LQSCQ 471_ TSEEC 476_ ELARA 481_NSTSD
1: Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:33257696, PubMed:36589890). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant (PubMed:36589890). By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed:33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (PubMed:18413611)