NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47)
1_MAAER 6_ QEALR 11_ EFVAV 16_ TGAEE 21_ DRARF 26_ FLESA 31_ GWDLQ 36_ IALAS 41_ FYEDG 46_ GDEDI 51_ VTISQ 56_ ATPSS 61_ VSRGT 66_ APSDN 71_ RVTSF 76_ RDLIH 81_ DQDED 86_ EEEEE 91_ GQRFY 96_ AGGSE 101_ RSGQQ 106_ IVGPP 111_ RKKSP 116_ NELVD 121_ DLFKG 126_ AKEHG 131_ AVAVE 136_ RVTKS 141_ PGETS 146_ KPRPF 151_ AGGGY 156_ RLGAA 161_ PEEES 166_ AYVAG 171_ EKRQH 176_ SSQDV 181_ HVVLK 186_ LWKSG 191_ FSLDN 196_ GELRS 201_ YQDPS 206_ NAQFL 211_ ESIRR 216_ GEVPA 221_ ELRRL 226_ AHGGQ 231_ VNLDM 236_ EDHRD 241_ EDFVK 246_ PKGAF 251_ KAFTG 256_ EGQKL 261_ GSTAP 266_ QVLST 271_ SSPAQ 276_ QAENE 281_ AKASS 286_ SILID 291_ ESEPT 296_ TNIQI 301_ RLADG 306_ GRLVQ 311_ KFNHS 316_ HRISD 321_ IRLFI 326_ VDARP 331_ AMAAT 336_ SFILM 341_ TTFPN 346_ KELAD 351_ ESQTL 356_ KEANL 361_LNAVI
1: Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807)