Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC)
1_MGSSE 6_ VSIIP 11_ GLQKE 16_ EKAAV 21_ ERRRL 26_ HVLKA 31_ LKKLR 36_ IEADE 41_ APVVA 46_ VLGSG 51_ GGLRA 56_ HIACL 61_ GVLSE 66_ MKEQG 71_ LLDAV 76_ TYLAG 81_ VSGST 86_ WAISS 91_ LYTND 96_ GDMEA 101_ LEADL 106_ KHRFT 111_ RQEWD 116_ LAKSL 121_ QKTIQ 126_ AARSE 131_ NYSLT 136_ DFWAY 141_ MVISK 146_ QTREL 151_ PESHL 156_ SNMKK 161_ PVEEG 166_ TLPYP 171_ IFAAI 176_ DNDLQ 181_ PSWQE 186_ ARAPE 191_ TWFEF 196_ TPHHA 201_ GFSAL 206_ GAFVS 211_ ITHFG 216_ SKFKK 221_ GRLVR 226_ THPER 231_ DLTFL 236_ RGLWG 241_ SALGN 246_ TEVIR 251_ EYIFD 256_ QLRNL 261_ TLKGL 266_ WRRAV 271_ ANAKS 276_ IGHLI 281_ FARLL 286_ RLQES 291_ SQGEH 296_ PPPED 301_ EGGEP 306_ EHTWL 311_ TEMLE 316_ NWTRT 321_ SLEKQ 326_ EQPHE 331_ DPERK 336_ GSLSN 341_ LMDFV 346_ KKTGI 351_ CASKW 356_ EWGTT 361_ HNFLY 366_ KHGGI 371_ RDKIM 376_ SSRKH 381_ LHLVD 386_ AGLAI 391_ NTPFP 396_ LVLPP 401_ TREVH 406_ LILSF 411_ DFSAG 416_ DPFET 421_ IRATT 426_ DYCRR 431_ HKIPF 436_ PQVEE 441_ AELDL 446_ WSKAP 451_ ASCYI 456_ LKGET 461_ GPVVM 466_ HFPLF 471_ NIDAC 476_ GGDIE 481_ AWSDT 486_ YDTFK 491_ LADTY 496_ TLDVV 501_ VLLLA 506_ LAKKN 511_ VRENK 516_ KKILR 521_ ELMNV 526_ AGLYY 531_ PKDSA 536_RSCCL
1: Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:10085124, PubMed:10358058, PubMed:19501189, PubMed:28336330, PubMed:9705332). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:10085124, PubMed:10358058, PubMed:19501189, PubMed:28336330, PubMed:9705332). Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids (PubMed:15944408, PubMed:19501189). Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency (PubMed:15944408, PubMed:19501189). In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles (PubMed:28336330)
2: (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV) (PubMed:23015700, PubMed:28336330). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur (PubMed:23015700). Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly (PubMed:23015700, PubMed:28336330)
3: (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission