Probable G-protein coupled receptor 34
1_MRSHT 6_ ITMTT 11_ TSVSS 16_ WPYSS 21_ HRMRF 26_ ITNHS 31_ DQPPQ 36_ NFSAT 41_ PNVTT 46_ CPMDE 51_ KLLST 56_ VLTTS 61_ YSVIF 66_ IVGLV 71_ GNIIA 76_ LYVFL 81_ GIHRK 86_ RNSIQ 91_ IYLLN 96_ VAIAD 101_ LLLIF 106_ CLPFR 111_ IMYHI 116_ NQNKW 121_ TLGVI 126_ LCKVV 131_ GTLFY 136_ MNMYI 141_ SIILL 146_ GFISL 151_ DRYIK 156_ INRSI 161_ QQRKA 166_ ITTKQ 171_ SIYVC 176_ CIVWM 181_ LALGG 186_ FLTMI 191_ ILTLK 196_ KGGHN 201_ STMCF 206_ HYRDK 211_ HNAKG 216_ EAIFN 221_ FILVV 226_ MFWLI 231_ FLLII 236_ LSYIK 241_ IGKNL 246_ LRISK 251_ RRSKF 256_ PNSGK 261_ YATTA 266_ RNSFI 271_ VLIIF 276_ TICFV 281_ PYHAF 286_ RFIYI 291_ SSQLN 296_ VSSCY 301_ WKEIV 306_ HKTNE 311_ IMLVL 316_ SSFNS 321_ CLDPV 326_ MYFLM 331_ SSNIR 336_ KIMCQ 341_ LLFRR 346_ FQGEP 351_ SRSES 356_ TSEFK 361_ PGYSL 366_ HDTSV 371_ AVKIQ 376_SSSKS
1: G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:16460680). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils (By similarity). Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (By similarity). Plays an important role in microglial function, controlling morphology and phagocytosis (By similarity)