Feline leukemia virus subgroup C receptor-related protein 2 (Calcium-chelate transporter) (CCT)
1_MVNEG 6_ PNQEE 11_ SDDTP 16_ VPESA 21_ LQADP 26_ SVSVH 31_ PSVSV 36_ HPSVS 41_ INPSV 46_ SVHPS 51_ SSAHP 56_ SALAQ 61_ PSGLA 66_ HPSSS 71_ GPEDL 76_ SVIKV 81_ SRRRW 86_ AVVLV 91_ FSCYS 96_ MCNSF 101_ QWIQY 106_ GSINN 111_ IFMHF 116_ YGVSA 121_ FAIDW 126_ LSMCY 131_ MLTYI 136_ PLLLP 141_ VAWLL 146_ EKFGL 151_ RTIAL 156_ TGSAL 161_ NCLGA 166_ WVKLG 171_ SLKPH 176_ LFPVT 181_ VVGQL 186_ ICSVA 191_ QVFIL 196_ GMPSR 201_ IASVW 206_ FGANE 211_ VSTAC 216_ SVAVF 221_ GNQLG 226_ IAIGF 231_ LVPPV 236_ LVPNI 241_ EDRDE 246_ LAYHI 251_ SIMFY 256_ IIGGV 261_ ATLLL 266_ ILVII 271_ VFKEK 276_ PKYPP 281_ SRAQS 286_ LSYAL 291_ TSPDA 296_ SYLGS 301_ IARLF 306_ KNLNF 311_ VLLVI 316_ TYGLN 321_ AGAFY 326_ ALSTL 331_ LNRMV 336_ IWHYP 341_ GEEVN 346_ AGRIG 351_ LTIVI 356_ AGMLG 361_ AVISG 366_ IWLDR 371_ SKTYK 376_ ETTLV 381_ VYIMT 386_ LVGMV 391_ VYTFT 396_ LNLGH 401_ LWVVF 406_ ITAGT 411_ MGFFM 416_ TGYLP 421_ LGFEF 426_ AVELT 431_ YPESE 436_ GISSG 441_ LLNIS 446_ AQVFG 451_ IIFTI 456_ SQGQI 461_ IDNYG 466_ TKPGN 471_ IFLCV 476_ FLTLG 481_ AALTA 486_ FIKAD 491_ LRRQK 496_ ANKET 501_ LENKL 506_ QEEEE 511_ ESNTS 516_ KVPTA 521_VSEDH
1: Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier (PubMed:38302740, PubMed:38778100). Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain (By similarity). Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine (By similarity). Also mediates transport of ethanolamine (PubMed:38778100). Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane (PubMed:38778100). However, the presence of an inwardly directed proton gradient enhances choline uptake (By similarity). Also acts as a heme b transporter (PubMed:20823265, PubMed:32973183). Required to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis (PubMed:32973183). At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis (PubMed:32973183). Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis (PubMed:32973183)