AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin)
1_MSDIV 6_ EKTLT 11_ ALPGL 16_ FLQNQ 21_ PGGGP 26_ AAAKA 31_ SFSSR 36_ LGSLV 41_ RGITA 46_ LTSKH 51_ EEEKL 56_ IQQEL 61_ SSLKA 66_ TVSAP 71_ TTTLK 76_ MMKEC 81_ MVRLI 86_ YCEML 91_ GYDAS 96_ FGYIH 101_ AIKLA 106_ QQGNL 111_ LEKRV 116_ GYLAV 121_ SLFLH 126_ ESHEL 131_ LLLLV 136_ NTVVK 141_ DLQST 146_ NLVEV 151_ CMALT 156_ VVSQI 161_ FPCEM 166_ IPAVL 171_ PLIED 176_ KLQHS 181_ KEIVR 186_ RKAVL 191_ ALYKF 196_ HLIAP 201_ NQVQH 206_ IHIKF 211_ RKALC 216_ DRDVG 221_ VMAAS 226_ LHIYL 231_ RMIKE 236_ NSSGY 241_ KDLTG 246_ SFVTI 251_ LKQVV 256_ GGKLP 261_ VEFNY 266_ HSVPA 271_ PWLQI 276_ QLLRI 281_ LGLLG 286_ KDDQR 291_ TSELM 296_ YDVLD 301_ ESLRR 306_ AELNH 311_ NVTYA 316_ ILFEC 321_ VHTVY 326_ SIYPK 331_ SELLE 336_ KAAKC 341_ IGKFV 346_ LSPKI 351_ NLKYL 356_ GLKAL 361_ TYVIQ 366_ QDPTL 371_ ALQHQ 376_ MTIIE 381_ CLDHP 386_ DPIIK 391_ RETLE 396_ LLYRI 401_ TNAQN 406_ ITVIV 411_ QKMLE 416_ YLHQS 421_ KEEYV 426_ IVNLV 431_ GKIAE 436_ LAEKY 441_ APDNA 446_ WFIQT 451_ MNAVF 456_ SVGGD 461_ VMHPD 466_ IPNNF 471_ LRLLA 476_ EGFDD 481_ ETEDQ 486_ QLRLY 491_ AVQSY 496_ LTLLD 501_ MENVF 506_ YPQRF 511_ LQVMS 516_ WVLGE 521_ YSYLL 526_ DKETP 531_ EEVIA 536_ KLYKL 541_ LMNDS 546_ VSSET 551_ KAWLI 556_ AAVTK 561_ LTSQA 566_ HSSNT 571_ VERLI 576_ HEFTI 581_ SLDTC 586_ MRQHA 591_ FELKH 596_ LHENV 601_ ELMKS 606_ LLPVD 611_ RSCED 616_ LVVDA 621_ SLSFL 626_ DGFVA 631_ EGLSQ 636_ GAAPY 641_ KPPHQ 646_ RQEEK 651_ LSQEK 656_ VLNFE 661_ PYGLS 666_ FSSSG 671_ FTGRQ 676_ SPAGI 681_ SLGSD 686_ VSGNS 691_ AETGL 696_ KETNS 701_ LKLEG 706_ IKKLW 711_ GKEGY 716_ LPKKE 721_ SKTGD 726_ ESGAL 731_ PVPQE 736_ SIMEN 741_ VDQAI 746_ TKKDQ 751_ SQVLT 756_ QSKEE 761_ KEKQL 766_ LASSL 771_ FVGLG 776_ SESTI 781_ NLLGK 786_ ADTVS 791_ HKFRR 796_ KSKVK 801_ EAKSG 806_ ETTST 811_ HNMTC 816_ SSFSS 821_ LSNVA 826_ YEDDY 831_ YSNTL 836_ HDTGD 841_ KELKK 846_ FSLTS 851_ ELLDS 856_ ESLTE 861_ LPLVE 866_ KFSYC 871_ SLSTP 876_ SLFAN 881_ NNMEI 886_ FHPPQ 891_ STAAS 896_ VAKES 901_ SLASS 906_ FLEET 911_ TEYIH 916_ SNAME 921_ VCNNE 926_ TISVS 931_ SYKIW 936_ KDDCL 941_ LMVWS 946_ VTNKS 951_ GLELK 956_ SADLE 961_ IFPAE 966_ NFKVT 971_ EQPGC 976_ CLPVM 981_ EAEST 986_ KSFQY 991_ SVQIE 996_ KPFTE 1001_ GNLTG 1006_ FISYH 1011_ MMDTH 1016_ SAQLE 1021_ FSVNL 1026_ SLLDF 1031_ IRPLK 1036_ ISSDD 1041_ FGKLW 1046_ LSFAN 1051_ DVKQN 1056_ VKMSE 1061_ SQAAL 1066_ PSALK 1071_ TLQQK 1076_ LRLHI 1081_ IEIIG 1086_ NEGLL 1091_ ACQLL 1096_ PSIPC 1101_ LLHCR 1106_ VHADV 1111_ LALWF 1116_ RSSCS 1121_ TLPDY 1126_ LLYQC 1131_QKVME
1: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable)