Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1)
1_MKGTR 6_ AIGSV 11_ PERSP 16_ AGVDL 21_ SLTGL 26_ PPPVS 31_ RRPGS 36_ AATTK 41_ PIVRS 46_ VSVVT 51_ GSEQK 56_ RKVLE 61_ ATGPG 66_ GSQAI 71_ NNLRR 76_ SNSTT 81_ QVSQP 86_ RSGSP 91_ RPTEP 96_ TDFLM 101_ LFEGS 106_ PSGKK 111_ RPASL 116_ STAPS 121_ EKGAT 126_ WNVLD 131_ DQPRG 136_ FTLPS 141_ NARSS 146_ SALDS 151_ PAGPR 156_ RKECT 161_ VALAP 166_ NFTAN 171_ NRSNK 176_ GAVGN 181_ CVTTM 186_ VHNRY 191_ TPSER 196_ APPLK 201_ SSNQT 206_ APSLN 211_ NIIKA 216_ ATCEG 221_ SESSG 226_ FGKLP 231_ KNVSS 236_ ATHSA 241_ RNNTG 246_ GSTGL 251_ PRRKE 256_ VTEEE 261_ AERFI 266_ HQVNQ 271_ ATVTI 276_ QRWYR 281_ HQVQR 286_ RGAGA 291_ ARLEH 296_ LLQAK 301_ REEQR 306_ QRSGE 311_ GTLLD 316_ LHQQK 321_ EAARR 326_ KAREE 331_ KARQA 336_ RRAAI 341_ QELQQ 346_ KRALR 351_ AQKAS 356_ TAERG 361_ PPENP 366_ RETRV 371_ PGMRQ 376_ PAQEL 381_ SPTPG 386_ GTAHQ 391_ ALKAN 396_ NTGGG 401_ LPAAG 406_ PGDRC 411_ LPTSD 416_ SSPEP 421_ QQPPE 426_ DRTQD 431_ VLAQD 436_ AAGDN 441_ LEMMA 446_ PSRGS 451_ AKSRG 456_ PLEEL 461_ LHTLQ 466_ LLEKE 471_ PDVLP 476_ RPRTH 481_ HRGRY 486_ AWASE 491_ VTTED 496_ DASSL 501_ TADNL 506_ EKFGK 511_ LSAFP 516_ EPPED 521_ GTLLS 526_ EAKLQ 531_ SIMSF 536_ LDEME 541_ KSGQD 546_ QLDSQ 551_ QEGWV 556_ PEAGP 561_ GPLEL 566_ GSEVS 571_ TSVMR 576_ LKLEV 581_ EEKKQ 586_ AMLLL 591_ QRALA 596_ QQRDL 601_ TARRV 606_ KETEK 611_ ALSRQ 616_ LQRQR 621_ EHYEA 626_ TIQRH 631_ LAFID 636_ QLIED 641_ KKVLS 646_ EKCEA 651_ VVAEL 656_ KQEDQ 661_ RCTER 666_ VAQAQ 671_ AQHEL 676_ EIKKL 681_ KELMS 686_ ATEKA 691_ RREKW 696_ ISEKT 701_ KKIKE 706_ VTVRG 711_ LEPEI 716_ QKLIA 721_ RHKQE 726_ VRRLK 731_ SLHEA 736_ ELLQS 741_ DERAS 746_ QRCLR 751_ QAEEL 756_ REQLE 761_ REKEA 766_ LGQQE 771_ RERAR 776_ QRFQQ 781_ HLEQE 786_ QWALQ 791_ QQRQR 796_ LYSEV 801_ AEERE 806_ RLGQQ 811_ AARQR 816_ AELEE 821_ LRQQL 826_ EESSS 831_ ALTRA 836_ LRAEF 841_ EKGRE 846_ EQERR 851_ HQMEL 856_ NTLKQ 861_ QLELE 866_ RQAWE 871_ AGRTR 876_ KEEAW 881_ LLNRE 886_ QELRE 891_ EIRKG 896_ RDKEI 901_ ELVIH 906_ RLEAD 911_ MALAK 916_ EESEK 921_ AAESR 926_ IKRLR 931_ DKYEA 936_ ELSEL 941_ EQSER 946_ KLQER 951_ CSELK 956_ GQLGE 961_ AEGEN 966_ LRLQG 971_ LVRQK 976_ ERALE 981_ DAQAV 986_ NEQLS 991_ SERSN 996_ LAQVI 1001_ RQEFE 1006_ DRLAA 1011_ SEEET 1016_ RQAKA 1021_ ELATL 1026_ QARQQ 1031_ LELEE 1036_ VHRRV 1041_ KTALA 1046_ RKEEA 1051_ VSSLR 1056_ TQHEA 1061_ AVKRA 1066_ DHLEE 1071_ LLEQH 1076_RRPTP
1: Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208)