E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)
1_MAENK 6_ GGGEA 11_ ESGGG 16_ GSGSA 21_ PVTAG 26_ AAGPA 31_ AQEAE 36_ PPLTA 41_ VLVEE 46_ EEEEG 51_ GRAGA 56_ EGGAA 61_ GPDDG 66_ GVAAA 71_ SSGSA 76_ QAASS 81_ PAASV 86_ GTGVA 91_ GGAVS 96_ TPAPA 101_ PASAP 106_ APGPS 111_ AGPPP 116_ GPPAS 121_ LLDTC 126_ AVCQQ 131_ SLQSR 136_ REAEP 141_ KLLPC 146_ LHSFC 151_ LRCLP 156_ EPERQ 161_ LSVPI 166_ PGGSN 171_ GDIQQ 176_ VGVIR 181_ CPVCR 186_ QECRQ 191_ IDLVD 196_ NYFVK 201_ DTSEA 206_ PSSSD 211_ EKSEQ 216_ VCTSC 221_ EDNAS 226_ AVGFC 231_ VECGE 236_ WLCKT 241_ CIEAH 246_ QRVKF 251_ TKDHL 256_ IRKKE 261_ DVSES 266_ VGASG 271_ QRPVF 276_ CPVHK 281_ QEQLK 286_ LFCET 291_ CDRLT 296_ CRDCQ 301_ LLEHK 306_ EHRYQ 311_ FLEEA 316_ FQNQK 321_ GAIEN 326_ LLAKL 331_ LEKKN 336_ YVHFA 341_ ATQVQ 346_ NRIKE 351_ VNETN 356_ KRVEQ 361_ EIKVA 366_ IFTLI 371_ NEINK 376_ KGKSL 381_ LQQLE 386_ NVTKE 391_ RQMKL 396_ LQQQN 401_ DITGL 406_ SRQVK 411_ HVMNF 416_ TNWAI 421_ ASGSS 426_ TALLY 431_ SKRLI 436_ TFQLR 441_ HILKA 446_ RCDPV 451_ PAANG 456_ AIRFH 461_ CDPTF 466_ WAKNV 471_ VNLGN 476_ LVIES 481_ KPAPG 486_ YTPNV 491_ VVGQV 496_ PPGTN 501_ HISKT 506_ PGQIN 511_ LAQLR 516_ LQHMQ 521_ QQVYA 526_ QKHQQ 531_ LQQMR 536_ MQQPP 541_ APVPT 546_ TTTTT 551_ QQHPR 556_ QAAPQ 561_ MLQQQ 566_ PPRLI 571_ SVQTM 576_ QRGNM 581_ NCGAF 586_ QAHQM 591_ RLAQN 596_ AARIP 601_ GIPRH 606_ SGPQY 611_ SMMQP 616_ HLQRQ 621_ HSNPG 626_ HAGPF 631_ PVVSV 636_ HNTTI 641_ NPTSP 646_ TTATM 651_ ANANR 656_ GPTSP 661_ SVTAI 666_ ELIPS 671_ VTNPE 676_ NLPSL 681_ PDIPP 686_ IQLED 691_ AGSSS 696_ LDNLL 701_ SRYIS 706_ GSHLP 711_ PQPTS 716_ TMNPS 721_ PGPSA 726_ LSPGS 731_ SGLSN 736_ SHTPV 741_ RPPST 746_ SSTGS 751_ RGSCG 756_ SSGRT 761_ AEKTS 766_ LSFKS 771_ DQVKV 776_ KQEPG 781_ TEDEI 786_ CSFSG 791_ GVKQE 796_ KTEDG 801_ RRSAC 806_ MLSSP 811_ ESSLT 816_ PPLST 821_ NLHLE 826_ SELDA 831_ LASLE 836_ NHVKI 841_ EPADM 846_ NESCK 851_ QSGLS 856_ SLVNG 861_ KSPIR 866_ SLMHR 871_ SARIG 876_ GDGNN 881_ KDDDP 886_ NEDWC 891_ AVCQN 896_ GGDLL 901_ CCEKC 906_ PKVFH 911_ LTCHV 916_ PTLLS 921_ FPSGD 926_ WICTF 931_ CRDIG 936_ KPEVE 941_ YDCDN 946_ LQHSK 951_ KGKTA 956_ QGLSP 961_ VDQRK 966_ CERLL 971_ LYLYC 976_ HELSI 981_ EFQEP 986_ VPASI 991_ PNYYK 996_ IIKKP 1001_ MDLST 1006_ VKKKL 1011_ QKKHS 1016_ QHYQI 1021_ PDDFV 1026_ ADVRL 1031_ IFKNC 1036_ ERFNE 1041_ MMKVV 1046_ QVYAD 1051_ TQEIN 1056_ LKADS 1061_ EVAQA 1066_ GKAVA 1071_ LYFED 1076_ KLTEI 1081_ YSDRT 1086_ FAPLP 1091_ EFEQE 1096_ EDDGE 1101_ VTEDS 1106_ DEDFI 1111_ QPRRK 1116_ RLKSD 1121_ERPVH
1: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade)