E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5)
1_MERSP 6_ DVSPG 11_ PSRSF 16_ KEELL 21_ CAVCY 26_ DPFRD 31_ AVTLR 36_ CGHNF 41_ CRGCV 46_ SRCWE 51_ VQVSP 56_ TCPVC 61_ KDRAS 66_ PADLR 71_ TNHTL 76_ NNLVE 81_ KLLRE 86_ EAEGA 91_ RWTSY 96_ RFSRV 101_ CRLHR 106_ GQLSL 111_ FCLED 116_ KELLC 121_ CSCQA 126_ DPRHQ 131_ GHRVQ 136_ PVKDT 141_ AHDFR 146_ AKCRN 151_ MEHAL 156_ REKAK 161_ AFWAM 166_ RRSYE 171_ AIAKH 176_ NQVEA 181_ AWLEG 186_ RIRQE 191_ FDKLR 196_ EFLRV 201_ EEQAI 206_ LDAMA 211_ EETRQ 216_ KQLLA 221_ DEKMK 226_ QLTEE 231_ TEVLA 236_ HEIER 241_ LQMEM 246_ KEDDV 251_ SFLMK 256_ HKSRK 261_ RRLFC 266_ TMEPE 271_ PVQPG 276_ MLIDV 281_ CKYLG 286_ SLQYR 291_ VWKKM 296_ LASVE 301_ SVPFS 306_ FDPNT 311_ AAGWL 316_ SVSDD 321_ LTSVT 326_ NHGYR 331_ VQVEN 336_ PERFS 341_ SAPCL 346_ LGSRV 351_ FSQGS 356_ HAWEV 361_ ALGGL 366_ QSWRV 371_ GVVRV 376_ RQDSG 381_ AEGHS 386_ HSCYH 391_ DTRSG 396_ FWYVC 401_ RTQGV 406_ EGDHC 411_ VTSDP 416_ ATSPL 421_ VLAIP 426_ RRLRV 431_ ELECE 436_ EGELS 441_ FYDAE 446_ RHCHL 451_ YTFHA 456_ RFGEV 461_ RPYFY 466_ LGGAR 471_ GAGPP 476_ EPLRI 481_ CPLHI 486_SVKEE
1: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439)