E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3)
1_MGFEL 6_ DRFDG 11_ DVDPD 16_ LKCAL 21_ CHKVL 26_ EDPLT 31_ TPCGH 36_ VFCAG 41_ CVLPW 46_ VVQEG 51_ SCPAR 56_ CRGRL 61_ SAKEL 66_ NHVLP 71_ LKRLI 76_ LKLDI 81_ KCAYA 86_ TRGCG 91_ RVVKL 96_ QQLPE 101_ HLERC 106_ DFAPA 111_ RCRHA 116_ GCGQV 121_ LLRRD 126_ VEAHM 131_ RDACD 136_ ARPVG 141_ RCQEG 146_ CGLPL 151_ THGEQ 156_ RAGGH 161_ CCARA 166_ LRAHN 171_ GALQA 176_ RLGAL 181_ HKALK 186_ KEALR 191_ AGKRE 196_ KSLVA 201_ QLAAA 206_ QLELQ 211_ MTALR 216_ YQKKF 221_ TEYSA 226_ RLDSL 231_ SRCVA 236_ APPGG 241_ KGEET 246_ KSLTL 251_ VLHRD 256_ SGSLG 261_ FNIIG 266_ GRPSV 271_ DNHDG 276_ SSSEG 281_ IFVSK 286_ IVDSG 291_ PAAKE 296_ GGLQI 301_ HDRII 306_ EVNGR 311_ DLSRA 316_ THDQA 321_ VEAFK 326_ TAKEP 331_ IVVQV 336_ LRRTP 341_ RTKMF 346_ TPPSE 351_ SQLVD 356_ TGTQT 361_ DITFE 366_ HIMAL 371_ TKMSS 376_ PSPPV 381_ LDPYL 386_ LPEEH 391_ PSAHE 396_ YYDPN 401_ DYIGD 406_ IHQEM 411_ DREEL 416_ ELEEV 421_ DLYRM 426_ NSQDK 431_ LGLTV 436_ CYRTD 441_ DEDDI 446_ GIYIS 451_ EIDPN 456_ SIAAK 461_ DGRIR 466_ EGDRI 471_ IQING 476_ IEVQN 481_ REEAV 486_ ALLTS 491_ EENKN 496_ FSLLI 501_ ARPEL 506_ QLDEG 511_ WMDDD 516_ RNDFL 521_ DDLHM 526_ DMLEE 531_ QHHQA 536_ MQFTA 541_ SVLQQ 546_ KKHDE 551_ DGGTT 556_ DTATI 561_ LSNQH 566_ EKDSG 571_ VGRTD 576_ ESTRN 581_ DESSE 586_ QENNG 591_ DDATA 596_ SSNPL 601_ AGQRK 606_ LTCSQ 611_ DTLGS 616_ GDLPF 621_ SNESF 626_ ISADC 631_ TDADY 636_ LGIPV 641_ DECER 646_ FRELL 651_ ELKCQ 656_ VKSAT 661_ PYGLY 666_ YPSGP 671_ LDAGK 676_ SDPES 681_ VDKEL 686_ ELLNE 691_ ELRSI 696_ ELECL 701_ SIVRA 706_ HKMQQ 711_ LKEQY 716_ RESWM 721_ LHNSG 726_ FRNYN 731_ TSIDV 736_ RRHEL 741_ SDITE 746_ LPEKS 751_ DKDSS 756_ SAYNT 761_ GESCR 766_ STPLT 771_ LEISP 776_ DNSLR 781_ RAAEG 786_ ISCPS 791_ SEGAV 796_ GTTEA 801_ YGPAS 806_ KNLLS 811_ ITEDP 816_ EVGTP 821_ TYSPS 826_ LKELD 831_ PNQPL 836_ ESKER 841_ RASDG 846_ SRSPT 851_ PSQKL 856_ GSAYL 861_ PSYHH 866_ SPYKH 871_ AHIPA 876_ HAQHY 881_ QSYMQ 886_ LIQQK 891_ SAVEY 896_ AQSQM 901_ SLVSM 906_ CKDLS 911_ SPTPS 916_ EPRME 921_ WKVKI 926_ RSDGT 931_ RYITK 936_ RPVRD 941_ RLLRE 946_ RALKI 951_ REERS 956_ GMTTD 961_ DDAVS 966_ EMKMG 971_ RYWSK 976_ EERKQ 981_ HLVKA 986_ KEQRR 991_ RREFM 996_ MQSRL 1001_ DCLKE 1006_ QQAAD 1011_ DRKEM 1016_ NILEL 1021_ SHKKM 1026_ MKKRN 1031_ KKIFD 1036_ NWMTI 1041_ QELLT 1046_ HGTKS 1051_ PDGTR 1056_ VYNSF 1061_LSVTT
1: E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation