Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5)
1_MSQGP 6_ PTGES 11_ SEPEA 16_ KVLHT 21_ KRLYR 26_ AVVEA 31_ VHRLD 36_ LILCN 41_ KTAYQ 46_ EVFKP 51_ ENISL 56_ RNKLR 61_ ELCVK 66_ LMFLH 71_ PVDYG 76_ RKAEE 81_ LLWRK 86_ VYYEV 91_ IQLIK 96_ TNKKH 101_ IHSRS 106_ TLECA 111_ YRTHL 116_ VAGIG 121_ FYQHL 126_ LLYIQ 131_ SHYQL 136_ ELQCC 141_ IDWTH 146_ VTDPL 151_ IGCKK 156_ PVSAS 161_ GKEMD 166_ WAQMA 171_ CHRCL 176_ VYLGD 181_ LSRYQ 186_ NELAG 191_ VDTEL 196_ LAERF 201_ YYQAL 206_ SVAPQ 211_ IGMPF 216_ NQLGT 221_ LAGSK 226_ YYNVE 231_ AMYCY 236_ LRCIQ 241_ SEVSF 246_ EGAYG 251_ NLKRL 256_ YDKAA 261_ KMYHQ 266_ LKKCE 271_ TRKLS 276_ PGKKR 281_ CKDIK 286_ RLLVN 291_ FMYLQ 296_ SLLQP 301_ KSSSV 306_ DSELT 311_ SLCQS 316_ VLEDF 321_ NLCLF 326_ YLPSS 331_ PNLSL 336_ ASEDE 341_ EEYES 346_ GYAFL 351_ PDLLI 356_ FQMVI 361_ ICLMC 366_ VHSLE 371_ RAGSK 376_ QYSAA 381_ IAFTL 386_ ALFSH 391_ LVNHV 396_ NIRLQ 401_ AELEE 406_ GENPV 411_ PAFQS 416_ DGTDE 421_ PESKE 426_ PVEKE 431_ EEPDP 436_ EPPPV 441_ TPQVG 446_ EGRKS 451_ RKFSR 456_ LSCLR 461_ RRRHP 466_ PKVGD 471_ DSDLS 476_ EGFES 481_ DSSHD 486_ SARAS 491_ EGSDS 496_ GSDKS 501_ LEGGG 506_ TAFDA 511_ ETDSE 516_ MNSQE 521_ SRSDL 526_ EDMEE 531_ EEGTR 536_ SPTLE 541_ PPRGR 546_ SEAPD 551_ SLNGP 556_ LGPSE 561_ ASIAS 566_ NLQAM 571_ STQMF 576_ QTKRC 581_ FRLAP 586_ TFSNL 591_ LLQPT 596_ TNPHT 601_ SASHR 606_ PCVNG 611_ DVDKP 616_ SEPAS 621_ EEGSE 626_ SEGSE 631_ SSGRS 636_ CRNER 641_ SIQEK 646_ LQVLM 651_ AEGLL 656_ PAVKV 661_ FLDWL 666_ RTNPD 671_ LIIVC 676_ AQSSQ 681_ SLWNR 686_ LSVLL 691_ NLLPA 696_ AGELQ 701_ ESGLA 706_ LCPEV 711_ QDLLE 716_ GCELP 721_ DLPSS 726_ LLLPE 731_ DMALR 736_ NLPPL 741_ RAAHR 746_ RFNFD 751_ TDRPL 756_ LSTLE 761_ ESVVR 766_ ICCIR 771_ SFGHF 776_ IARLQ 781_ GSILQ 786_ FNPEV 791_ GIFVS 796_ IAQSE 801_ QESLL 806_ QQAQA 811_ QFRMA 816_ QEEAR 821_ RNRLM 826_ RDMAQ 831_ LRLQL 836_ EVSQL 841_ EGSLQ 846_ QPKAQ 851_ SAMSP 856_ YLVPD 861_ TQALC 866_ HHLPV 871_ IRQLA 876_ TSGRF 881_ IVIIP 886_ RTVID 891_ GLDLL 896_ KKEHP 901_ GARDG 906_ IRYLE 911_ AEFKK 916_ GNRYI 921_ RCQKE 926_ VGKSF 931_ ERHKL 936_ KRQDA 941_ DAWTL 946_ YKILD 951_ SCKQL 956_ TLAQG 961_ AGEED 966_ PSGMV 971_ TIITG 976_ LPLDN 981_ PSVLS 986_ GPMQA 991_ ALQAA 996_ AHASV 1001_ DIKNV 1006_ LDFYK 1011_QWKEI
1: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity