C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
1_MMEIQ 6_ MDEGG 11_ GVVVY 16_ QDDYC 21_ SGSVM 26_ SERVS 31_ GLAGS 36_ IYREF 41_ ERLIH 46_ CYDEE 51_ VVKEL 56_ MPLVV 61_ NVLEN 66_ LDSVL 71_ SENQE 76_ HEVEL 81_ ELLRE 86_ DNEQL 91_ LTQYE 96_ REKAL 101_ RRQAE 106_ EKFIE 111_ FEDAL 116_ EQEKK 121_ ELQIQ 126_ VEHYE 131_ FQTRQ 136_ LELKA 141_ KNYAD 146_ QISRL 151_ EERES 156_ EMKKE 161_ YNALH 166_ QRHTE 171_ MIQTY 176_ VEHIE 181_ RSKMQ 186_ QVGGN 191_ SQTES 196_ SLPGR 201_ RKERP 206_ TSLNV 211_ FPLAD 216_ GTVRA 221_ QIGGK 226_ LVPAG 231_ DHWHL 236_ SDLGQ 241_ LQSSS 246_ SYQCP 251_ QDEMS 256_ ESGQS 261_ SAAAT 266_ PSTTG 271_ TKSNT 276_ PTSSV 281_ PSAAV 286_ TPLNE 291_ SLQPL 296_ GDYGV 301_ GSKNS 306_ KRARE 311_ KRDSR 316_ NMEVQ 321_ VTQEM 326_ RNVSI 331_ GMGSS 336_ DEWSD 341_ VQDII 346_ DSTPE 351_ LDMCP 356_ ETRLD 361_ RTGSS 366_ PTQGI 371_ VNKAF 376_ GINTD 381_ SLYHE 386_ LSTAG 391_ SEVIG 396_ DVDEG 401_ ADLLG 406_ EFSVR 411_ DDFFG 416_ MGKEV 421_ GNLLL 426_ ENSQL 431_ LETKN 436_ ALNVV 441_ KNDLI 446_ AKVDQ 451_ LSGEQ 456_ EVLRG 461_ ELEAA 466_ KQAKV 471_ KLENR 476_ IKELE 481_ EELKR 486_ VKSEA 491_ IIARR 496_ EPKEE 501_ AEDVS 506_ SYLCT 511_ ESDKI 516_ PMAQR 521_ RRFTR 526_ VEMAR 531_ VLMER 536_ NQYKE 541_ RLMEL 546_ QEAVR 551_ WTEMI 556_ RASRE 561_ HPSVQ 566_ EKKKS 571_ TIWQF 576_ FSRLF 581_ SSSSS 586_ PPPAK 591_ RPYPS 596_ VNIHY 601_ KSPTT 606_ AGFSQ 611_ RRNHA 616_ MCPIS 621_ AGSRP 626_ LEFFP 631_ DDDCT 636_ SSARR 641_ EQKRE 646_ QYRQV 651_ REHVR 656_ NDDGR 661_ LQACG 666_ WSLPA 671_ KYKQL 676_ SPNGG 681_ QEDTR 686_ MKNVP 691_ VPVYC 696_ RPLVE 701_ KDPTM 706_ KLWCA 711_ AGVNL 716_ SGWRP 721_ NEDDA 726_ GNGVK 731_ PAPGR 736_ DPLTC 741_ DREGD 746_ GEPKS 751_ AHTSP 756_ EKKKA 761_ KELPE 766_ MDATS 771_ SRVWI 776_ LTSTL 781_ TTSKV 786_ VIIDA 791_ NQPGT 796_ VVDQF 801_ TVCNA 806_ HVLCI 811_ SSIPA 816_ ASDSD 821_ YPPGE 826_ MFLDS 831_ DVNPE 836_ DPGAD 841_ GVLAG 846_ ITLVG 851_ CATRC 856_ NVPRS 861_ NCSSR 866_ GDTPV 871_ LDKGQ 876_ GEVAT 881_ IANGK 886_ VNPSQ 891_ STEEA 896_ TEATE 901_ VPDPG 906_ PSEPE 911_ TATLR 916_ PGPLT 921_ EHVFT 926_ DPAPT 931_ PSSGP 936_ QPGSE 941_ NGPEP 946_ DSSST 951_ RPEPE 956_ PSGDP 961_ TGAGS 966_ SAAPT 971_ MWLGA 976_ QNGWL 981_ YVHSA 986_ VANWK 991_ KCLHS 996_ IKLKD 1001_ SVLSL 1006_ VHVKG 1011_ RVLVA 1016_ LADGT 1021_ LAIFH 1026_ RGEDG 1031_ QWDLS 1036_ NYHLM 1041_ DLGHP 1046_ HHSIR 1051_ CMAVV 1056_ YDRVW 1061_ CGYKN 1066_ KVHVI 1071_ QPKTM 1076_ QIEKS 1081_ FDAHP 1086_ RRESQ 1091_ VRQLA 1096_ WIGDG 1101_ VWVSI 1106_ RLDST 1111_ LRLYH 1116_ AHTHQ 1121_ HLQDV 1126_ DIEPY 1131_ VSKML 1136_ GTGKL 1141_ GFSFV 1146_ RITAL 1151_ LVAGS 1156_ RLWVG 1161_ TGNGV 1166_ VISIP 1171_ LTETV 1176_ VLHRG 1181_ QLLGL 1186_ RANKT 1191_ SPTSG 1196_ EGARP 1201_ GGIIH 1206_ VYGDD 1211_ SSDRA 1216_ ASSFI 1221_ PYCSM 1226_ AQAQL 1231_ CFHGH 1236_ RDAVK 1241_ FFVSV 1246_ PGNVL 1251_ ATLNG 1256_ SVLDS 1261_ PAEGP 1266_ GPAAP 1271_ ASEVE 1276_ GQKLR 1281_ NVLVL 1286_ SGGEG 1291_ YIDFR 1296_ IGDGE 1301_ DDETE 1306_ EGAGD 1311_ MSQVK 1316_ PVLSK 1321_ AERSH 1326_ IIVWQ 1331_VSYTP
1: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604)