Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1)
1_MSKLK 6_ VIPEK 11_ SLTNN 16_ SRIVG 21_ LLAQL 26_ EKINA 31_ EPSES 36_ DTARY 41_ VTSKI 46_ LHLAQ 51_ SQEKT 56_ RREMT 61_ AKGST 66_ GMEIL 71_ LSTLE 76_ NTKDL 81_ QTTLN 86_ ILSIL 91_ VELVS 96_ AGGGR 101_ RVSFL 106_ VTKGG 111_ SQILL 116_ QLLMN 121_ ASKES 126_ PPHED 131_ LMVQI 136_ HSILA 141_ KIGPK 146_ DKKFG 151_ VKARI 156_ NGALN 161_ ITLNL 166_ VKQNL 171_ QNHRL 176_ VLPCL 181_ QLLRV 186_ YSANS 191_ VNSVS 196_ LGKNG 201_ VVELM 206_ FKIIG 211_ PFSKK 216_ NSSLI 221_ KVALD 226_ TLAAL 231_ LKSKT 236_ NARRA 241_ VDRGY 246_ VQVLL 251_ TIYVD 256_ WHRHD 261_ NRHRN 266_ MLIRK 271_ GILQS 276_ LKSVT 281_ NIKLG 286_ RKAFI 291_ DANGM 296_ KILYN 301_ TSQEC 306_ LAVRT 311_ LDPLV 316_ NTSSL 321_ IMRKC 326_ FPKNR 331_ LPLPT 336_ IKSSF 341_ HFQLP 346_ VIPVT 351_ GPVAQ 356_ LYSLP 361_ PEVDD 366_ VVDES 371_ DDNDD 376_ IDVEA 381_ ENETE 386_ NEDDL 391_ DQNFK 396_ NDDIE 401_ TDINK 406_ LKPQQ 411_ EPGRT 416_ IEDLK 421_ MYEHL 426_ FPELV 431_ DDFQD 436_ YDLIS 441_ KEPKP 446_ FVFEG 451_ KVRGP 456_ IVVPT 461_ AGEET 466_ SGNSG 471_ NLRKV 476_ VMKEN 481_ ISSKG 486_ DEGEK 491_ KSTFM 496_ DLAKE 501_ DIKDN 506_ DRTLQ 511_ QQPGD 516_ QNRTI 521_ SSVHG 526_ LNNDI 531_ VKALD 536_ RITLQ 541_ NIPSQ 546_ TAPGF 551_ TAEMK 556_ KDCSL 561_ PLTVL 566_ TCAKA 571_ CPHMA 576_ TCGNV 581_ LFEGR 586_ TVQLG 591_ KLCCT 596_ GVETE 601_ DDEDT 606_ ESNSS 611_ VEQAS 616_ VEVPD 621_ GPTLH 626_ DPDLY 631_ IEIVK 636_ NTKSV 641_ PEYSE 646_ VAYPD 651_ YFGHI 656_ PPPFK 661_ EPILE 666_ RPYGV 671_ QRTKI 676_ AQDIE 681_ RLIHQ 686_ SDIID 691_ RVVYD 696_ LDNPN 701_ YTIPE 706_ EGDIL 711_ KFNSK 716_ FESGN 721_ LRKVI 726_ QIRKN 731_ EYDLI 736_ LNSDI 741_ NSNHY 746_ HQWFY 751_ FEVSG 756_ MRPGV 761_ AYRFN 766_ IINCE 771_ KSNSQ 776_ FNYGM 781_ QPLMY 786_ SVQEA 791_ LNARP 796_ WWIRM 801_ GTDIC 806_ YYKNH 811_ FSRSS 816_ VAAGG 821_ QKGKS 826_ YYTIT 831_ FTVNF 836_ PHKDD 841_ VCYFA 846_ YHYPY 851_ TYSTL 856_ QMHLQ 861_ KLESA 866_ HNPQQ 871_ IYFRK 876_ DVLCE 881_ TLSGN 886_ SCPLV 891_ TITAM 896_ PESNY 901_ YEHIC 906_ HFRNR 911_ PYVFL 916_ SARVH 921_ PGETN 926_ ASWVM 931_ KGTLE 936_ YLMSN 941_ NPTAQ 946_ SLRES 951_ YIFKI 956_ VPMLN 961_ PDGVI 966_ NGNHR 971_ CSLSG 976_ EDLNR 981_ QWQSP 986_ SPDLH 991_ PTIYH 996_ AKGLL 1001_ QYLAA 1006_ VKRLP 1011_ LVYCD 1016_ YHGHS 1021_ RKKNV 1026_ FMYGC 1031_ SIKET 1036_ VWHTN 1041_ DNATS 1046_ CDVVE 1051_ DTGYR 1056_ TLPKI 1061_ LSHIA 1066_ PAFCM 1071_ SSCSF 1076_ VVEKS 1081_ KESTA 1086_ RVVVW 1091_ REIGV 1096_ QRSYT 1101_ MESTL 1106_ CGCDQ 1111_ GKYKG 1116_ LQIGT 1121_ RELEE 1126_ MGAKF 1131_ CVGLL 1136_ RLKRL 1141_ TSPLE 1146_ YNLPS 1151_ SLLDF 1156_ ENDLI 1161_ ESSCK 1166_ VTSPT 1171_ TYVLD 1176_ EDEPR 1181_ FLEEV 1186_ DYSAE 1191_ SNDEL 1196_ DIELA 1201_ ENVGD 1206_ YEPSA 1211_ QEEVL 1216_ SDSEL 1221_SRTYL
1: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216)