Gene name: SHANK2

Uniprot entry:

Q9UPX8

Protein names:

SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)

Protein sequence:

1_MPRSP 6_ TSSED 11_ EMAQS 16_ FSDYS 21_ VGSES 26_ DSSKE 31_ ETIYD 36_ TIRAT 41_ AEKPG 46_ GARTE 51_ ESQGN 56_ TLVIR 61_ VVIHD 66_ LQQTK 71_ CIRFN 76_ PDATV 81_ WVAKQ 86_ RILCT 91_ LTQSL 96_ KDVLN 101_ YGLFQ 106_ PASNG 111_ RDGKF 116_ LDEER 121_ LLREY 126_ PQPVG 131_ EGVPS 136_ LEFRY 141_ KKRVY 146_ KQASL 151_ DEKQL 156_ AKLHT 161_ KTNLK 166_ KCMDH 171_ IQHRL 176_ VEKIT 181_ KMLDR 186_ GLDPN 191_ FHDPE 196_ TGETP 201_ LTLAA 206_ QLDDS 211_ VEVIK 216_ ALKNG 221_ GAHLD 226_ FRAKD 231_ GMTAL 236_ HKAAR 241_ ARNQV 246_ ALKTL 251_ LELGA 256_ SPDYK 261_ DSYGL 266_ TPLYH 271_ TAIVG 276_ GDPYC 281_ CELLL 286_ HEHAT 291_ VCCKD 296_ ENGWH 301_ EIHQA 306_ CRYGH 311_ VQHLE 316_ HLLFY 321_ GADMS 326_ AQNAS 331_ GNTAL 336_ HICAL 341_ YNQDS 346_ CARVL 351_ LFRGG 356_ NKELK 361_ NYNSQ 366_ TPFQV 371_ AIIAG 376_ NFELA 381_ EYIKN 386_ HKETD 391_ IVPFR 396_ EAPAY 401_ SNRRR 406_ RPPNT 411_ LAAPR 416_ VLLRS 421_ NSDNN 426_ LNASA 431_ PDWAV 436_ CSTAT 441_ SHRSL 446_ SPQLL 451_ QQMPS 456_ KPEGA 461_ AKTIG 466_ SYVPG 471_ PRSRS 476_ PSLNR 481_ LGGAG 486_ EDGKR 491_ PQPLW 496_ HVGSP 501_ FALGA 506_ NKDSL 511_ SAFEY 516_ PGPKR 521_ KLYSA 526_ VPGRL 531_ FVAVK 536_ PYQPQ 541_ VDGEI 546_ PLHRG 551_ DRVKV 556_ LSIGE 561_ GGFWE 566_ GSARG 571_ HIGWF 576_ PAECV 581_ EEVQC 586_ KPRDS 591_ QAETR 596_ ADRSK 601_ KLFRH 606_ YTVGS 611_ YDSFD 616_ TSSDC 621_ IIEEK 626_ TVVLQ 631_ KKDNE 636_ GFGFV 641_ LRGAK 646_ ADTPI 651_ EEFTP 656_ TPAFP 661_ ALQYL 666_ ESVDE 671_ GGVAW 676_ QAGLR 681_ TGDFL 686_ IEVNN 691_ ENVVK 696_ VGHRQ 701_ VVNMI 706_ RQGGN 711_ HLVLK 716_ VVTVT 721_ RNLDP 726_ DDTAR 731_ KKAPP 736_ PPKRA 741_ PTTAL 746_ TLRSK 751_ SMTSE 756_ LEELV 761_ DKASV 766_ RKKKD 771_ KPEEI 776_ VPASK 781_ PSRAA 786_ ENMAV 791_ EPRVA 796_ TIKQR 801_ PSSRC 806_ FPAGS 811_ DMNSV 816_ YERQG 821_ IAVMT 826_ PTVPG 831_ SPKAP 836_ FLGIP 841_ RGTMR 846_ RQKSI 851_ DSRIF 856_ LSGIT 861_ EEERQ 866_ FLAPP 871_ MLKFT 876_ RSLSM 881_ PDTSE 886_ DIPPP 891_ PQSVP 896_ PSPPP 901_ PSPTT 906_ YNCPK 911_ SPTPR 916_ VYGTI 921_ KPAFN 926_ QNSAA 931_ KVSPA 936_ TRSDT 941_ VATMM 946_ REKGM 951_ YFRRE 956_ LDRYS 961_ LDSED 966_ LYSRN 971_ AGPQA 976_ NFRNK 981_ RGQMP 986_ ENPYS 991_ EVGKI 996_ ASKAV 1001_ YVPAK 1006_ PARRK 1011_ GMLVK 1016_ QSNVE 1021_ DSPEK 1026_ TCSIP 1031_ IPTII 1036_ VKEPS 1041_ TSSSG 1046_ KSSQG 1051_ SSMEI 1056_ DPQAP 1061_ EPPSQ 1066_ LRPDE 1071_ SLTVS 1076_ SPFAA 1081_ AIAGA 1086_ VRDRE 1091_ KRLEA 1096_ RRNSP 1101_ AFLST 1106_ DLGDE 1111_ DVGLG 1116_ PPAPR 1121_ TRPSM 1126_ FPEEG 1131_ DFADE 1136_ DSAEQ 1141_ LSSPM 1146_ PSATP 1151_ REPEN 1156_ HFVGG 1161_ AEASA 1166_ PGEAG 1171_ RPLNS 1176_ TSKAQ 1181_ GPESS 1186_ PAVPS 1191_ ASSGT 1196_ AGPGN 1201_ YVHPL 1206_ TGRLL 1211_ DPSSP 1216_ LALAL 1221_ SARDR 1226_ AMKES 1231_ QQGPK 1236_ GEAPK 1241_ ADLNK 1246_ PLYID 1251_ TKMRP 1256_ SLDAG 1261_ FPTVT 1266_ RQNTR 1271_ GPLRR 1276_ QETEN 1281_ KYETD 1286_ LGRDR 1291_ KGDDK 1296_ KNMLI 1301_ DIMDT 1306_ SQQKS 1311_ AGLLM 1316_ VHTVD 1321_ ATKLD 1326_ NALQE 1331_ EDEKA 1336_ EVEMK 1341_ PDSSP 1346_ SEVPE 1351_ GVSET 1356_ EGALQ 1361_ ISAAP 1366_ EPTTV 1371_ PGRTI 1376_ VAVGS 1381_ MEEAV 1386_ ILPFR 1391_ IPPPP 1396_ LASVD 1401_ LDEDF 1406_ IFTEP 1411_ LPPPL 1416_ EFANS 1421_ FDIPD 1426_ DRAAS 1431_ VPALS 1436_ DLVKQ 1441_ KKSDT 1446_ PQSPS 1451_ LNSSQ 1456_ PTNSA 1461_ DSKKP 1466_ ASLSN 1471_ CLPAS 1476_ FLPPP 1481_ ESFDA 1486_ VADSG 1491_ IEEVD 1496_ SRSSS 1501_ DHHLE 1506_ TTSTI 1511_ STVSS 1516_ ISTLS 1521_ SEGGE 1526_ NVDTC 1531_ TVYAD 1536_ GQAFM 1541_ VDKPP 1546_ VPPKP 1551_ KMKPI 1556_ IHKSN 1561_ ALYQD 1566_ ALVEE 1571_ DVDSF 1576_ VIPPP 1581_ APPPP 1586_ PGSAQ 1591_ PGMAK 1596_ VLQPR 1601_ TSKLW 1606_ GDVTE 1611_ IKSPI 1616_ LSGPK 1621_ ANVIS 1626_ ELNSI 1631_ LQQMN 1636_ REKLA 1641_ KPGEG 1646_ LDSPM 1651_ GAKSA 1656_ SLAPR 1661_ SPEIM 1666_ STISG 1671_ TRSTT 1676_ VTFTV 1681_ RPGTS 1686_ QPITL 1691_ QSRPP 1696_ DYESR 1701_ TSGTR 1706_ RAPSP 1711_ VVSPT 1716_ EMNKE 1721_ TLPAP 1726_ LSAAT 1731_ ASPSP 1736_ ALSDV 1741_ FSLPS 1746_ QPPSG 1751_ DLFGL 1756_ NPAGR 1761_ SRSPS 1766_ PSILQ 1771_ QPISN 1776_ KPFTT 1781_ KPVHL 1786_ WTKPD 1791_ VADWL 1796_ ESLNL 1801_ GEHKE 1806_ AFMDN 1811_ EIDGS 1816_ HLPNL 1821_ QKEDL 1826_ IDLGV 1831_ TRVGH 1836_ RMNIE 1841_RALKQ

Protein annotations

Protein functions:

1: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction