Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)
1_MKSPA 6_ LQPLS 11_ MAGLQ 16_ LMTPA 21_ SSPMG 26_ PFFGL 31_ PWQQE 36_ AIHDN 41_ IYTPR 46_ KYQVE 51_ LLEAA 56_ LDHNT 61_ IVCLN 66_ TGSGK 71_ TFIAV 76_ LLTKE 81_ LSYQI 86_ RGDFS 91_ RNGKR 96_ TVFLV 101_ NSANQ 106_ VAQQV 111_ SAVRT 116_ HSDLK 121_ VGEYS 126_ NLEVN 131_ ASWTK 136_ ERWNQ 141_ EFTKH 146_ QVLIM 151_ TCYVA 156_ LNVLK 161_ NGYLS 166_ LSDIN 171_ LLVFD 176_ ECHLA 181_ ILDHP 186_ YREIM 191_ KLCEN 196_ CPSCP 201_ RILGL 206_ TASIL 211_ NGKCD 216_ PEELE 221_ EKIQK 226_ LEKIL 231_ KSNAE 236_ TATDL 241_ VVLDR 246_ YTSQP 251_ CEIVV 256_ DCGPF 261_ TDRSG 266_ LYERL 271_ LMELE 276_ EALNF 281_ INDCN 286_ ISVHS 291_ KERDS 296_ TLISK 301_ QILSD 306_ CRAVL 311_ VVLGP 316_ WCADK 321_ VAGMM 326_ VRELQ 331_ KYIKH 336_ EQEEL 341_ HRKFL 346_ LFTDT 351_ FLRKI 356_ HALCE 361_ EHFSP 366_ ASLDL 371_ KFVTP 376_ KVIKL 381_ LEILR 386_ KYKPY 391_ ERQQF 396_ ESVEW 401_ YNNRN 406_ QDNYV 411_ SWSDS 416_ EDDDE 421_ DEEIE 426_ EKEKP 431_ ETNFP 436_ SPFTN 441_ ILCGI 446_ IFVER 451_ RYTAV 456_ VLNRL 461_ IKEAG 466_ KQDPE 471_ LAYIS 476_ SNFIT 481_ GHGIG 486_ KNQPR 491_ NKQME 496_ AEFRK 501_ QEEVL 506_ RKFRA 511_ HETNL 516_ LIATS 521_ IVEEG 526_ VDIPK 531_ CNLVV 536_ RFDLP 541_ TEYRS 546_ YVQSK 551_ GRARA 556_ PISNY 561_ IMLAD 566_ TDKIK 571_ SFEED 576_ LKTYK 581_ AIEKI 586_ LRNKC 591_ SKSVD 596_ TGETD 601_ IDPVM 606_ DDDDV 611_ FPPYV 616_ LRPDD 621_ GGPRV 626_ TINTA 631_ IGHIN 636_ RYCAR 641_ LPSDP 646_ FTHLA 651_ PKCRT 656_ RELPD 661_ GTFYS 666_ TLYLP 671_ INSPL 676_ RASIV 681_ GPPMS 686_ CVRLA 691_ ERVVA 696_ LICCE 701_ KLHKI 706_ GELDD 711_ HLMPV 716_ GKETV 721_ KYEEE 726_ LDLHD 731_ EEETS 736_ VPGRP 741_ GSTKR 746_ RQCYP 751_ KAIPE 756_ CLRDS 761_ YPRPD 766_ QPCYL 771_ YVIGM 776_ VLTTP 781_ LPDEL 786_ NFRRR 791_ KLYPP 796_ EDTTR 801_ CFGIL 806_ TAKPI 811_ PQIPH 816_ FPVYT 821_ RSGEV 826_ TISIE 831_ LKKSG 836_ FMLSL 841_ QMLEL 846_ ITRLH 851_ QYIFS 856_ HILRL 861_ EKPAL 866_ EFKPT 871_ DADSA 876_ YCVLP 881_ LNVVN 886_ DSSTL 891_ DIDFK 896_ FMEDI 901_ EKSEA 906_ RIGIP 911_ STKYT 916_ KETPF 921_ VFKLE 926_ DYQDA 931_ VIIPR 936_ YRNFD 941_ QPHRF 946_ YVADV 951_ YTDLT 956_ PLSKF 961_ PSPEY 966_ ETFAE 971_ YYKTK 976_ YNLDL 981_ TNLNQ 986_ PLLDV 991_ DHTSS 996_ RLNLL 1001_ TPRHL 1006_ NQKGK 1011_ ALPLS 1016_ SAEKR 1021_ KAKWE 1026_ SLQNK 1031_ QILVP 1036_ ELCAI 1041_ HPIPA 1046_ SLWRK 1051_ AVCLP 1056_ SILYR 1061_ LHCLL 1066_ TAEEL 1071_ RAQTA 1076_ SDAGV 1081_ GVRSL 1086_ PADFR 1091_ YPNLD 1096_ FGWKK 1101_ SIDSK 1106_ SFISI 1111_ SNSSS 1116_ AENDN 1121_ YCKHS 1126_ TIVPE 1131_ NAAHQ 1136_ GANRT 1141_ SSLEN 1146_ HDQMS 1151_ VNCRT 1156_ LLSES 1161_ PGKLH 1166_ VEVSA 1171_ DLTAI 1176_ NGLSY 1181_ NQNLA 1186_ NGSYD 1191_ LANRD 1196_ FCQGN 1201_ QLNYY 1206_ KQEIP 1211_ VQPTT 1216_ SYSIQ 1221_ NLYSY 1226_ ENQPQ 1231_ PSDEC 1236_ TLLSN 1241_ KYLDG 1246_ NANKS 1251_ TSDGS 1256_ PVMAV 1261_ MPGTT 1266_ DTIQV 1271_ LKGRM 1276_ DSEQS 1281_ PSIGY 1286_ SSRTL 1291_ GPNPG 1296_ LILQA 1301_ LTLSN 1306_ ASDGF 1311_ NLERL 1316_ EMLGD 1321_ SFLKH 1326_ AITTY 1331_ LFCTY 1336_ PDAHE 1341_ GRLSY 1346_ MRSKK 1351_ VSNCN 1356_ LYRLG 1361_ KKKGL 1366_ PSRMV 1371_ VSIFD 1376_ PPVNW 1381_ LPPGY 1386_ VVNQD 1391_ KSNTD 1396_ KWEKD 1401_ EMTKD 1406_ CMLAN 1411_ GKLDE 1416_ DYEEE 1421_ DEEEE 1426_ SLMWR 1431_ APKEE 1436_ ADYED 1441_ DFLEY 1446_ DQEHI 1451_ RFIDN 1456_ MLMGS 1461_ GAFVK 1466_ KISLS 1471_ PFSTT 1476_ DSAYE 1481_ WKMPK 1486_ KSSLG 1491_ SMPFS 1496_ SDFED 1501_ FDYSS 1506_ WDAMC 1511_ YLDPS 1516_ KAVEE 1521_ DDFVV 1526_ GFWNP 1531_ SEENC 1536_ GVDTG 1541_ KQSIS 1546_ YDLHT 1551_ EQCIA 1556_ DKSIA 1561_ DCVEA 1566_ LLGCY 1571_ LTSCG 1576_ ERAAQ 1581_ LFLCS 1586_ LGLKV 1591_ LPVIK 1596_ RTDRE 1601_ KALCP 1606_ TRENF 1611_ NSQQK 1616_ NLSVS 1621_ CAAAS 1626_ VASSR 1631_ SSVLK 1636_ DSEYG 1641_ CLKIP 1646_ PRCMF 1651_ DHPDA 1656_ DKTLN 1661_ HLISG 1666_ FENFE 1671_ KKINY 1676_ RFKNK 1681_ AYLLQ 1686_ AFTHA 1691_ SYHYN 1696_ TITDC 1701_ YQRLE 1706_ FLGDA 1711_ ILDYL 1716_ ITKHL 1721_ YEDPR 1726_ QHSPG 1731_ VLTDL 1736_ RSALV 1741_ NNTIF 1746_ ASLAV 1751_ KYDYH 1756_ KYFKA 1761_ VSPEL 1766_ FHVID 1771_ DFVQF 1776_ QLEKN 1781_ EMQGM 1786_ DSELR 1791_ RSEED 1796_ EEKEE 1801_ DIEVP 1806_ KAMGD 1811_ IFESL 1816_ AGAIY 1821_ MDSGM 1826_ SLETV 1831_ WQVYY 1836_ PMMRP 1841_ LIEKF 1846_ SANVP 1851_ RSPVR 1856_ ELLEM 1861_ EPETA 1866_ KFSPA 1871_ ERTYD 1876_ GKVRV 1881_ TVEVV 1886_ GKGKF 1891_ KGVGR 1896_ SYRIA 1901_ KSAAA 1906_ RRALR 1911_ SLKAN 1916_QPQVP
1: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes