Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)
1_MVRKP 6_ VVSTI 11_ SKGGY 16_ LQGNV 21_ NGRLP 26_ SLGNK 31_ EPPGQ 36_ EKVQL 41_ KRKVT 46_ LLRGV 51_ SIIIG 56_ TIIGA 61_ GIFIS 66_ PKGVL 71_ QNTGS 76_ VGMSL 81_ TIWTV 86_ CGVLS 91_ LFGAL 96_ SYAEL 101_ GTTIK 106_ KSGGH 111_ YTYIL 116_ EVFGP 121_ LPAFV 126_ RVWVE 131_ LLIIR 136_ PAATA 141_ VISLA 146_ FGRYI 151_ LEPFF 156_ IQCEI 161_ PELAI 166_ KLITA 171_ VGITV 176_ VMVLN 181_ SMSVS 186_ WSARI 191_ QIFLT 196_ FCKLT 201_ AILII 206_ IVPGV 211_ MQLIK 216_ GQTQN 221_ FKDAF 226_ SGRDS 231_ SITRL 236_ PLAFY 241_ YGMYA 246_ YAGWF 251_ YLNFV 256_ TEEVE 261_ NPEKT 266_ IPLAI 271_ CISMA 276_ IVTIG 281_ YVLTN 286_ VAYFT 291_ TINAE 296_ ELLLS 301_ NAVAV 306_ TFSER 311_ LLGNF 316_ SLAVP 321_ IFVAL 326_ SCFGS 331_ MNGGV 336_ FAVSR 341_ LFYVA 346_ SREGH 351_ LPEIL 356_ SMIHV 361_ RKHTP 366_ LPAVI 371_ VLHPL 376_ TMIML 381_ FSGDL 386_ DSLLN 391_ FLSFA 396_ RWLFI 401_ GLAVA 406_ GLIYL 411_ RYKCP 416_ DMHRP 421_ FKVPL 426_ FIPAL 431_ FSFTC 436_ LFMVA 441_ LSLYS 446_ DPFST 451_ GIGFV 456_ ITLTG 461_ VPAYY 466_ LFIIW 471_ DKKPR 476_ WFRIM 481_ SEKIT 486_ RTLQI 491_ ILEVV 496_PEEDK
1: Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:11133847, PubMed:11417227, PubMed:14722095, PubMed:15151999, PubMed:34880232, PubMed:35245456, PubMed:35352032). Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress (By similarity). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine (PubMed:11133847, PubMed:11417227). In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis (PubMed:35245456). Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis (PubMed:34120018). In vitro can also transport L-aspartate (PubMed:11417227). May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (By similarity). Controls the production of pheomelanin pigment directly (By similarity)