Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3)
1_MAVNV 6_ YSTSV 11_ TSENL 16_ SRHDM 21_ LAWVN 26_ DSLHL 31_ NYTKI 36_ EQLCS 41_ GAAYC 46_ QFMDM 51_ LFPGC 56_ VHLRK 61_ VKFQA 66_ KLEHE 71_ YIHNF 76_ KVLQA 81_ AFKKM 86_ GVDKI 91_ IPVEK 96_ LVKGK 101_ FQDNF 106_ EFIQW 111_ FKKFF 116_ DANYD 121_ GKDYN 126_ PLLAR 131_ QGQDV 136_ APPPN 141_ PGDQI 146_ FNKSK 151_ KLIGT 156_ AVPQR 161_ TSPTG 166_ PKNMQ 171_ TSGRL 176_ SNVAP 181_ PCILR 186_ KNPPS 191_ ARNGG 196_ HETDA 201_ QILEL 206_ NQQLV 211_ DLKLT 216_ VDGLE 221_ KERDF 226_ YFSKL 231_ RDIEL 236_ ICQEH 241_ ESENS 246_ PVISG 251_ IIGIL 256_ YATEE 261_ GFAPP 266_ EDDEI 271_ EEHQQ 276_EDQDE
1: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:19255245, PubMed:28814570). Promotes microtubule growth (PubMed:19255245, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:19255245, PubMed:28814570). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570)