Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog)
1_MSSSL 6_ GKEKD 11_ SKEKD 16_ PKVPS 21_ AKERE 26_ KEAKA 31_ SGGFG 36_ KESKE 41_ KEPKT 46_ KGKDA 51_ KDGKK 56_ DSSAA 61_ QPGVA 66_ FSVDN 71_ TIKRP 76_ NPAPG 81_ TRKKS 86_ SNAEV 91_ IKELN 96_ KCREE 101_ NSMRL 106_ DLSKR 111_ SIHIL 116_ PSSIK 121_ ELTQL 126_ TELYL 131_ YSNKL 136_ QSLPA 141_ EVGCL 146_ VNLMT 151_ LALSE 156_ NSLTS 161_ LPDSL 166_ DNLKK 171_ LRMLD 176_ LRHNK 181_ LREIP 186_ SVVYR 191_ LDSLT 196_ TLYLR 201_ FNRIT 206_ TVEKD 211_ IKNLS 216_ KLSML 221_ SIREN 226_ KIKQL 231_ PAEIG 236_ ELCNL 241_ ITLDV 246_ AHNQL 251_ EHLPK 256_ EIGNC 261_ TQITN 266_ LDLQH 271_ NELLD 276_ LPDTI 281_ GNLSS 286_ LSRLG 291_ LRYNR 296_ LSAIP 301_ RSLAK 306_ CSALE 311_ ELNLE 316_ NNNIS 321_ TLPES 326_ LLSSL 331_ VKLNS 336_ LTLAR 341_ NCFQL 346_ YPVGG 351_ PSQFS 356_ TIYSL 361_ NMEHN 366_ RINKI 371_ PFGIF 376_ SRAKV 381_ LSKLN 386_ MKDNQ 391_ LTSLP 396_ LDFGT 401_ WTSMV 406_ ELNLA 411_ TNQLT 416_ KIPED 421_ VSGLV 426_ SLEVL 431_ ILSNN 436_ LLKKL 441_ PHGLG 446_ NLRKL 451_ RELDL 456_ EENKL 461_ ESLPN 466_ EIAYL 471_ KDLQK 476_ LVLTN 481_ NQLTT 486_ LPRGI 491_ GHLTN 496_ LTHLG 501_ LGENL 506_ LTHLP 511_ EEIGT 516_ LENLE 521_ ELYLN 526_ DNPNL 531_ HSLPF 536_ ELALC 541_ SKLSI 546_ MSIEN 551_ CPLSH 556_ LPPQI 561_ VAGGP 566_ SFIIQ 571_ FLKMQ 576_GPYRA
1: Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (PubMed:10783161, PubMed:16630891, PubMed:25137548, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Acts as a scaffolding protein in the SMP complex (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:10783161, PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670)