Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1)
1_MSGED 6_ EQQEQ 11_ TIAED 16_ LVVTK 21_ YKMGG 26_ DIANR 31_ VLRSL 36_ VEASS 41_ SGVSV 46_ LSLCE 51_ KGDAM 56_ IMEET 61_ GKIFK 66_ KEKEM 71_ KKGIA 76_ FPTSI 81_ SVNNC 86_ VCHFS 91_ PLKSD 96_ QDYIL 101_ KEGDL 106_ VKIDL 111_ GVHVD 116_ GFIAN 121_ VAHTF 126_ VVDVA 131_ QGTQV 136_ TGRKA 141_ DVIKA 146_ AHLCA 151_ EAALR 156_ LVKPG 161_ NQNTQ 166_ VTEAW 171_ NKVAH 176_ SFNCT 181_ PIEGM 186_ LSHQL 191_ KQHVI 196_ DGEKT 201_ IIQNP 206_ TDQQK 211_ KDHEK 216_ AEFEV 221_ HEVYA 226_ VDVLV 231_ SSGEG 236_ KAKDA 241_ GQRTT 246_ IYKRD 251_ PSKQY 256_ GLKMK 261_ TSRAF 266_ FSEVE 271_ RRFDA 276_ MPFTL 281_ RAFED 286_ EKKAR 291_ MGVVE 296_ CAKHE 301_ LLQPF 306_ NVLYE 311_ KEGEF 316_ VAQFK 321_ FTVLL 326_ MPNGP 331_ MRITS 336_ GPFEP 341_ DLYKS 346_ EMEVQ 351_ DAELK 356_ ALLQS 361_ SASRK 366_ TQKKK 371_ KKKAS 376_ KTAEN 381_ ATSGE 386_TLEEN
1: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity)